Disruption of social bonds induces behavioral and physiological dysregulation in male and female prairie voles.
Disruption of social bonds induces behavioral and physiological dysregulation in male and female prairie voles.
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DOI：
10.1016/j.autneu.2013.10.001
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发表时间：
2014-02
影响因子：
2.7
通讯作者：
Grippo, Angela J.
中科院分区：
文献类型：
--
作者：
McNeal, Neal;Scotti, Melissa-Ann L.;Wardwell, Joshua;Chandler, Danielle L.;Bates, Suzanne L.;LaRocca, Meagan;Trahanas, Diane M.;Grippo, Angela J.
关键词：
失去伴侣的社会混乱可能对心理和生理功能产生特别强烈的不利影响。更具体地说，社会压力可能在心境障碍和心血管功能障碍之间的关联中发挥中介作用。本研究探讨了一种假说，即雄性和雌性草原田鼠之间建立的社会联系的中断会产生抑郁行为和心脏失调，再加上内分泌和自主神经系统功能障碍。在实验1中，抑郁症，心脏功能和自主神经系统调节相关的行为进行了监测，在男性草原田鼠与女性合作伙伴的社会联系，社会隔离的债券合作伙伴，和行为应激。社会隔离产生抑郁行为，心率增加，心律失调，以及自主神经失调，其特征是交感神经驱动心脏增加，副交感神经驱动心脏减少。在实验2中，抑郁症和内分泌功能的相关行为进行了测量后，社会联系和社会隔离的男性和女性草原田鼠。社会隔离产生了类似水平的抑郁行为在两种性别，以及显着升高的促肾上腺皮质激素和皮质酮。这些行为和生理功能的改变提供了对社会压力对人类情绪和心血管健康产生负面影响的机制的深入了解。
The social disruption of losing a partner may have particularly strong adverse effects on psychological and physiological functioning. More specifically, social stressors may play a mediating role in the association between mood disorders and cardiovascular dysfunction. This study investigated the hypothesis that the disruption of established social bonds between male and female prairie voles would produce depressive behaviors and cardiac dysregulation, coupled with endocrine and autonomic nervous system dysfunction. In Experiment 1, behaviors related to depression, cardiac function, and autonomic nervous system regulation were monitored in male prairie voles during social bonding with a female partner, social isolation from the bonded partner, and a behavioral stressor. Social isolation produced depressive behaviors, increased heart rate, heart rhythm dysregulation, and autonomic imbalance characterized by increased sympathetic and decreased parasympathetic drive to the heart. In Experiment 2, behaviors related to depression and endocrine function were measured following social bonding and social isolation in both male and female prairie voles. Social isolation produced similar levels of depressive behaviors in both sexes, as well as significant elevations of adrenocorticotropic hormone and corticosterone. These alterations in behavioral and physiological functioning provide insight into the mechanisms by which social stressors negatively influence emotional and cardiovascular health in humans.
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DOI：
10.1073/pnas.92.17.7744
发表时间：
1995-08-15
影响因子：
11.1
作者：
DEVRIES, AC;DEVRIES, MB;CARTER, CS
通讯作者：
CARTER, CS
影响因子：
5
作者：
BLAZER, DG
通讯作者：
BLAZER, DG
影响因子：
3.3
作者：
Carney RM;Steinmeyer B;Freedland KE;Blumenthal JA;Stein PK;Steinhoff WA;Howells WB;Berkman LF;Watkins LL;Czajkowski SM;Domitrovich PP;Burg MM;Hayano J;Jaffe AS
通讯作者：
Jaffe AS
影响因子：
3.3
作者：
Eisenberger NI
通讯作者：
Eisenberger NI
影响因子：
2.9
作者：
Bales, KL;Kramer, KM;Carter, CS
通讯作者：
Carter, CS