Mother-infant interactions in free-ranging rhesus macaques: relationships between physiological and behavioral variables.
Mother-infant interactions in free-ranging rhesus macaques: relationships between physiological and behavioral variables.
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DOI：
10.1016/j.physbeh.2008.12.016
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发表时间：
2009-03-23
影响因子：
2.9
通讯作者：
Higley, James D.
中科院分区：
文献类型：
--
作者：
Maestripieri, Dario;Hoffman, Christy L.;Anderson, George M.;Carter, C. Sue;Higley, James D.
关键词：
对非人灵长类动物母婴关系的研究越来越多地试图了解育儿方式个体间差异的神经内分泌基础，以及早期接触不同育儿方式影响婴儿行为发展的机制。在波多黎各圣地亚哥岛的自由放养恒河猴的研究中，我们的目的是：1)比较哺乳期和非哺乳期雌性恒河猴，研究哺乳期是否与血浆皮质醇、催乳素和催产素的变化以及脑脊液中血清素和多巴胺代谢产物（5-HIAA和HVA）水平的变化有关；2)检查母亲生理的个体间差异与母亲行为差异的关联程度；3)检查婴儿生理和行为的个体间差异在多大程度上是由母亲生理和行为的差异造成的。哺乳期女性血浆皮质醇、催乳素和催产素浓度高于非哺乳期女性，但脑脊液HVA浓度低于非哺乳期女性。母体排斥行为的变化与母体血浆皮质醇水平和CSF 5-HIAA水平的变化呈正相关，而护理和梳洗时间的变化与母体血浆催产素水平相关。受到母亲更多保护的婴儿的皮质醇水平比受到较少保护的婴儿高，而受到更多排斥的婴儿的CSF 5-HIAA水平比受到较少排斥的婴儿低。由于已知暴露于高水平的母亲保护和排斥会影响后代在以后的生活中对环境的行为和反应，我们的结果与假设一致，即这些影响是由后代HPA轴和大脑血清素能系统活动的长期变化介导的。
Studies of mother–infant relationships in nonhuman primates have increasingly attempted to understand the neuroendocrine bases of interindividual variation in mothering styles and the mechanisms through which early exposure to variable mothering styles affects infant behavioral development. In this study of free-ranging rhesus macaques on Cayo Santiago, Puerto Rico, we aimed to: 1) compare lactating and nonlactating females to investigate whether lactation is associated with changes in plasma cortisol, prolactin and oxytocin, as well as changes in CSF levels of serotonin and dopamine metabolites (5-HIAA and HVA); 2) examine the extent to which interindividual variation in maternal physiology is associated with variation in maternal behavior; 3) examine the extent to which interindividual variation in infant physiology and behavior is accounted for by variation in maternal physiology and behavior. Lactating females had higher plasma concentrations of cortisol, prolactin, and oxytocin but lower CSF concentrations of HVA than nonlactating females. Variation in maternal rejection behavior was positively correlated with variation in maternal plasma cortisol levels and in CSF 5-HIAA levels while variation in the time spent nursing and grooming was associated with maternal plasma oxytocin levels. Infants who were protected more by their mothers had higher cortisol levels than those who were protected less, while infants who were rejected more had lower CSF 5-HIAA than infants who were rejected less. Since exposure to high levels of maternal protectiveness and rejection is known to affect the offspring’s behavior and responsiveness to the environment later in life, our results are consistent with the hypothesis that these effects are mediated by long-term changes in the activity of the offspring’s HPA axis and brain serotonergic system.
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影响因子：
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作者：
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通讯作者：
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