Memory-guided reaching in a patient with visual hemiagnosia
Memory-guided reaching in a patient with visual hemiagnosia
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视觉偏盲患者的记忆引导伸手
DOI：
10.1016/j.cortex.2016.03.010
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发表时间：
2016
期刊：
影响因子：
3.6
通讯作者：
M. Himmelbach
中科院分区：
文献类型：
--
作者：
S. Cornelsen;J. Rennig;M. Himmelbach
双视觉系统假说（TVSH）假设记忆引导的运动依赖于腹侧流的完整功能。它对记忆引导行动的特别重要性最初是从著名的DF患者的行为分离中推断出来的。尽管她对可见目标的到达和抓取动作相当准确，但她表现出严重受损的记忆引导抓取和受损的记忆引导到达。这些分离后来在背侧损伤和视神经共济失调患者中被明显逆转的分离所补充。然而，DF和视神经共济失调患者的抓握研究在目标物体的视网膜定位方面存在差异，对各自发现的双重分离的解释提出了质疑。相比之下，两种类型的患者的发现到达错误来自相似的外周靶表现。然而，关于DF的大脑结构变化和视觉运动缺陷的新数据也质疑双重分离在到达中的有效性。DF严重的视觉空间短期记忆缺陷进一步质疑了她的记忆引导到达缺陷的特异性。因此，我们比较了视觉引导和记忆引导下到达的运动准确性，该患者因中风而遭受局限性单侧腹侧视觉系统损伤。我们的结果确实支持了先前关于记忆引导运动在DF中的不准确性的描述。此外，我们的数据表明，最近在DF中发现的类似光学共济失调的误伸很可能是由她的顶枕神经损伤引起的，而不是由她的腹侧神经损伤引起的。最后，HWS的多重视觉空间记忆测量表明，腹侧损伤患者在记忆引导下的到达任务中的不准确性不能用视觉空间短期记忆或知觉缺陷来解释，而是由视觉运动加工的特定缺陷来解释。
The two-visual-systems hypothesis (TVSH) postulates that memory-guided movements rely on intact functions of the ventral stream. Its particular importance for memory-guided actions was initially inferred from behavioral dissociations in the well-known patient DF. Despite of rather accurate reaching and grasping movements to visible targets, she demonstrated grossly impaired memory-guided grasping as much as impaired memory-guided reaching. These dissociations were later complemented by apparently reversed dissociations in patients with dorsal damage and optic ataxia. However, grasping studies in DF and optic ataxia patients differed with respect to the retinotopic position of target objects, questioning the interpretation of the respective findings as a double dissociation. In contrast, the findings for reaching errors in both types of patients came from similar peripheral target presentations. However, new data on brain structural changes and visuomotor deficits in DF also questioned the validity of a double dissociation in reaching. A severe visuospatial short-term memory deficit in DF further questioned the specificity of her memory-guided reaching deficit. Therefore, we compared movement accuracy in visually-guided and memory-guided reaching in a new patient who suffered a confined unilateral damage to the ventral visual system due to stroke. Our results indeed support previous descriptions of memory-guided movements' inaccuracies in DF. Furthermore, our data suggest that recently discovered optic-ataxia like misreaching in DF is most likely caused by her parieto-occipital and not by her ventral stream damage. Finally, multiple visuospatial memory measurements in HWS suggest that inaccuracies in memory-guided reaching tasks in patients with ventral damage cannot be explained by visuospatial short-term memory or perceptual deficits, but by a specific deficit in visuomotor processing.
DOI：
10.1073/pnas.92.18.8135
发表时间：
1995-08-29
影响因子：
11.1
作者：
MALACH, R;REPPAS, JB;TOOTELL, RBH
通讯作者：
TOOTELL, RBH
影响因子：
5.7
作者：
Fiehler, Katja;Bannert, Michael M.;Roesler, Frank
通讯作者：
Roesler, Frank
人类深部大脑 MRI 图谱。
影响因子：
3.4
作者：
Lemaire,Jean-Jacques;DeSalles,Antonio;Coll,Guillaume;ElOuadih,Youssef;Chaix,Rémi;Coste,Jérôme;Durif,Franck;Makris,Nikos;Kikinis,Ron
通讯作者：
Kikinis,Ron