New insights into the evasion of host innate immunity by Mycobacterium tuberculosis.
New insights into the evasion of host innate immunity by Mycobacterium tuberculosis.
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关于结核分枝杆菌逃避宿主先天免疫的新见解
DOI：
10.1038/s41423-020-0502-z
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发表时间：
2020-09
影响因子：
24.1
通讯作者：
Ge B
中科院分区：
文献类型：
--
作者：
Chai Q;Wang L;Liu CH;Ge B
结核分枝杆菌（Mtb）是一种非常成功的细胞内病原体，它导致结核病（TB），结核病仍然是人类死亡的主要感染性原因。结核分枝杆菌与宿主先天免疫系统的早期相互作用在很大程度上决定了结核感染的建立和疾病的发展。感染后，宿主细胞通过一组先天免疫受体检测结核分枝杆菌，并启动一系列细胞先天免疫事件。然而，这些先天防御机制被结核分枝杆菌广泛调节以避免宿主免疫清除。在这篇综述中，我们描述了细胞质核酸传感途径在宿主-结核分枝杆菌界面上的新作用，并总结了最近发现的结核分枝杆菌绕过宿主细胞固有免疫策略（如膜运输和完整性、细胞死亡和自噬）的机制。此外，我们还讨论了新近阐明的Mtb操纵宿主先天免疫分子调控机制的策略，包括核内调控机制、泛素系统和细胞内在免疫成分。更好地了解结核分枝杆菌采用的先天免疫逃避机制将为结核病发病机制提供新的见解，并有助于开发更有效的结核病疫苗和治疗方法。
Mycobacterium tuberculosis (Mtb) is an extremely successful intracellular pathogen that causes tuberculosis (TB), which remains the leading infectious cause of human death. The early interactions between Mtb and the host innate immune system largely determine the establishment of TB infection and disease development. Upon infection, host cells detect Mtb through a set of innate immune receptors and launch a range of cellular innate immune events. However, these innate defense mechanisms are extensively modulated by Mtb to avoid host immune clearance. In this review, we describe the emerging role of cytosolic nucleic acid-sensing pathways at the host–Mtb interface and summarize recently revealed mechanisms by which Mtb circumvents host cellular innate immune strategies such as membrane trafficking and integrity, cell death and autophagy. In addition, we discuss the newly elucidated strategies by which Mtb manipulates the host molecular regulatory machinery of innate immunity, including the intranuclear regulatory machinery, the ubiquitin system, and cellular intrinsic immune components. A better understanding of innate immune evasion mechanisms adopted by Mtb will provide new insights into TB pathogenesis and contribute to the development of more effective TB vaccines and therapies.
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影响因子：
7
作者：
Barber GN
通讯作者：
Barber GN
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
9
作者：
通讯作者：
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结核分枝杆菌表面蛋白招募泛素来触发宿主异体吞噬
影响因子：
16.6
作者：
Chai, Qiyao;Wang, Xudong;Liu, Cui Hua
通讯作者：
Liu, Cui Hua
影响因子：
11.4
作者：
Abdullah, Zeinab;Schlee, Martin;Knolle, Percy A.
通讯作者：
Knolle, Percy A.