Cortisol Modulation by Ayahuasca in Patients With Treatment Resistant Depression and Healthy Controls.
Cortisol Modulation by Ayahuasca in Patients With Treatment Resistant Depression and Healthy Controls.
复制标题
DOI：
10.3389/fpsyt.2018.00185
复制
发表时间：
2018
影响因子：
4.7
通讯作者：
Galvão-Coelho NL
中科院分区：
文献类型：
--
作者：
Galvão ACM;de Almeida RN;Silva EADS;Freire FAM;Palhano-Fontes F;Onias H;Arcoverde E;Maia-de-Oliveira JP;de Araújo DB;Lobão-Soares B;Galvão-Coelho NL
重度抑郁症是一种非常普遍的情绪障碍，影响约3.5亿人，约30%的患者对目前可用的抗抑郁药物有抗药性。最近来自随机对照试验（RCT）的证据支持迷幻ayahuasca在难治性抑郁症中的快速抗抑郁作用。本研究的目的是探讨死藤水对同一组治疗抵抗患者（MD）和健康志愿者（C）的血浆皮质醇和唤醒唾液皮质醇反应的影响。受试者接受单剂量的死藤水或安慰剂（给药期），在基线（给药期前）和给药期后48小时测量血浆和唤醒唾液皮质醇反应。与健康对照组相比，基线评估（D0）显示患者的觉醒唾液皮质醇反应迟钝和低皮质醇血症。在给药期间还测量了唾液皮质醇，我们观察到摄入死藤水的C和MD的增加高于安慰剂。在服用死藤水48小时后，患者的觉醒唾液皮质醇反应与对照组相似。48小时后，观察到血浆皮质醇水平没有显着变化。因此，这些研究结果指出，在健康和抑郁的志愿者中，ayahuasca会议导致唾液皮质醇水平的调节。考虑到皮质醇在调节不同的生理途径、情绪和认知过程中起作用，它被认为与抑郁症的病因学密切相关，并且其调节似乎对治疗和缓解重度抑郁症很重要，应进一步研究死藤水作为抗抑郁剂的用途。此外，这项研究强调了致幻剂在治疗人类精神障碍方面的重要性。
Major depression is a highly prevalent mood disorder, affecting about 350 million people, and around 30% of the patients are resistant to currently available antidepressant medications. Recent evidence from a randomized controlled trial (RCT) supports the rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression. The aim of this study was to explore the effect of ayahuasca on plasma cortisol and awakening salivary cortisol response, in the same group of treatment-resistant patients (MD) and in healthy volunteers (C). Subjects received a single dose of ayahuasca or placebo (dosing session), and both plasma and awakening salivary cortisol response were measured at baseline (before dosing session) and 48 h after the dosing session. Baseline assessment (D0) showed blunted awakening salivary cortisol response and hypocortisolemia in patients, with respect to healthy controls. Salivary cortisol was also measured during dosing session, and we observed higher increases for both C and MD that ingested ayahuasca than placebo. After 48 h from the dosing session with ayahuasca, patients' awakening salivary cortisol response is similar to the ones detected in controls. No significant changes in plasma cortisol levels were observed 48 h after the sessions. Therefore, these findings point to new evidence on the modulation of salivary cortisol levels as a result of an ayahuasca session, both in healthy and depressive volunteers. Considering that cortisol acts in regulation of distinct physiological pathways, emotional and cognitive processes, it is assumed to be critically involved to the etiology of depression and its regulation seems to be important for the treatment and remission of major depression, ayahuasca use as antidepressant should be further investigated. Moreover, this study highlights the importance of psychedelics in the treatment of human mental disorders.
登录
查看更多内容
影响因子：
3.4
作者：
Carbonaro, Theresa M.;Eshleman, Amy J.;Forster, Michael J.;Cheng, Kejun;Rice, Kenner C.;Gatch, Michael B.
通讯作者：
Gatch, Michael B.
影响因子：
10.6
作者：
Bremmer, Marijke A.;Deeg, Dorly J. H.;Hoogendijk, Witte J. G.
通讯作者：
Hoogendijk, Witte J. G.
DOI：
10.3109/10253890.2011.596864
发表时间：
2011-09
期刊：
Stress (Amsterdam, Netherlands)
影响因子：
--
作者：
Campeau S;Liberzon I;Morilak D;Ressler K
通讯作者：
Ressler K
DOI：
10.1164/rccm.200509-1369oc
发表时间：
2006-12-15
影响因子：
24.7
作者：
Annane, Djillali;Maxime, Virginie;Boudou, Philippe
通讯作者：
Boudou, Philippe
影响因子：
3.7
作者：
Carlos Bouso, Jose;Gonzalez, Debora;Riba, Jordi
通讯作者：
Riba, Jordi