Stress modulation of cognitive and affective processes.
Stress modulation of cognitive and affective processes.
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DOI：
10.3109/10253890.2011.596864
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发表时间：
2011-09
期刊：
影响因子：
--
通讯作者：
Ressler K
中科院分区：
文献类型：
--
作者：
Campeau S;Liberzon I;Morilak D;Ressler K
本综述总结了 2010 年压力神经生物学研讨会（美国科罗拉多州博尔德）期间举行的认知和情感过程压力调节研讨会的主要讨论要点。四位讨论者讨论了一些通过暴露于急性或反复压力而调节的特定认知和情感因素。 David Morilak 博士讨论了各种重复压力情况对认知灵活性的影响（通过注意力转移任务的啮齿动物模型进行评估），以及不同前额叶区域如何通过单胺能神经传递来调节该测试中略有不同方面的表现。 Serge Campeau 博士总结了几项研究的结果，这些研究探索了调节各种自主神经和神经内分泌对重复听源压力暴露的反应的习惯性的因素和大脑区域。 Kerry Ressler 博士讨论了一系列探索啮齿动物和人类恐惧记忆调节和消除的工作，特别关注关键神经递质系统的作用，包括兴奋性氨基酸和脑源性神经营养因子。 Israel Liberzon 博士介绍了人类对外源性糖皮质激素给药决策过程的最新结果。总的来说，这些讨论为认知/情感过程建立了更广泛的框架，这些过程明显受到压力体验以及与这些影响相关的一些大脑区域和神经递质系统的调节。
This review summarizes the major discussion points of a symposium on stress modulation of cognitive and affective processes, which was held during the 2010 workshop on the neurobiology of stress (Boulder, CO, USA). The four discussants addressed a number of specific cognitive and affective factors that are modulated by exposure to acute or repeated stress. Dr David Morilak discussed the effects of various repeated stress situations on cognitive flexibility, as assessed with a rodent model of attentional set-shifting task, and how performance on slightly different aspects of this test is modulated by different prefrontal regions through monoaminergic neurotransmission. Dr Serge Campeau summarized the findings of several studies exploring a number of factors and brain regions that regulate habituation of various autonomic and neuroendocrine responses to repeated audiogenic stress exposures. Dr Kerry Ressler discussed a body of work exploring the modulation and extinction of fear memories in rodents and humans, especially focusing on the role of key neurotransmitter systems including excitatory amino acids and brain-derived neurotrophic factor. Dr Israel Liberzon presented recent results on human decision-making processes in response to exogenous glucocorticoid hormone administration. Overall, these discussions are casting a wider framework on the cognitive/affective processes that are distinctly regulated by the experience of stress and some of the brain regions and neurotransmitter systems associated with these effects.
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影响因子：
120.7
作者：
Binder, Elisabeth B.;Bradley, Rebekah G.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.
影响因子：
56.9
作者：
CAREW, TJ;PINSKER, HM;KANDEL, ER
通讯作者：
KANDEL, ER
影响因子：
6.9
作者：
Bremner, JD;Vermetten, E;Charney, DS
通讯作者：
Charney, DS
DOI：
10.1016/j.pnpbp.2010.04.016
发表时间：
2010-08-16
影响因子：
5.6
作者：
Bondi, Corina O.;Jett, Julianne D.;Morilak, David A.
通讯作者：
Morilak, David A.
影响因子：
3.2
作者：
Bao, G;Metreveli, N;Fletcher, EC
通讯作者：
Fletcher, EC