Paternal cocaine taking elicits epigenetic remodeling and memory deficits in male progeny.
Paternal cocaine taking elicits epigenetic remodeling and memory deficits in male progeny.
复制标题
父亲可卡因吸引雄性后代的表观遗传重塑和记忆缺陷。
DOI：
10.1038/mp.2017.8
复制
发表时间：
2017-11
影响因子：
11
通讯作者：
Pierce RC
中科院分区：
文献类型：
--
作者：
Wimmer ME;Briand LA;Fant B;Guercio LA;Arreola AC;Schmidt HD;Sidoli S;Han Y;Garcia BA;Pierce RC
Paternal environmental perturbations including exposure to drugs of abuse can produce profound effects on the physiology and behavior of offspring via epigenetic modifications. Here we show that adult drug-naive male offspring of cocaine-exposed sires have memory formation deficits and associated reductions in NMDA receptor-mediated hippocampal synaptic plasticity. Reduced levels of the endogenous NMDA receptor co-agonist D-serine were accompanied by increased expression of the D-serine degrading enzyme d-amino acid oxidase (Dao1) in the hippocampus of cocaine-sired male progeny. Increased Dao1 transcription was associated with enrichment of permissive epigenetic marks on histone proteins in the hippocampus of male cocaine-sired progeny, some of which were enhanced near the Dao1 locus. Finally, hippocampal administration of D-serine reversed both the memory formation and synaptic plasticity deficits. Collectively, these results demonstrate that paternal cocaine exposure produces epigenetic remodeling in the hippocampus leading to NMDA receptor-dependent memory formation and synaptic plasticity impairments only in male progeny, which has significant implications for the male descendants of chronic cocaine users.
登录
查看更多内容
影响因子：
64.5
作者：
Carone BR;Fauquier L;Habib N;Shea JM;Hart CE;Li R;Bock C;Li C;Gu H;Zamore PD;Meissner A;Weng Z;Hofmann HA;Friedman N;Rando OJ
通讯作者：
Rando OJ
影响因子：
4.2
作者：
Aharonovich, E;Hasin, DS;Nunes, EV
通讯作者：
Nunes, EV
影响因子：
14.5
作者：
Curcio, Livia;Podda, Maria V.;D'Ascenzo, Marcello
通讯作者：
D'Ascenzo, Marcello
影响因子：
25
作者：
Dias, Brian G.;Ressier, Kerry J.
通讯作者：
Ressier, Kerry J.
影响因子：
2.7
作者：
Blokland, Arjan;Rutten, Kris;Prickaerts, Jos
通讯作者：
Prickaerts, Jos