Sickle Cell Trait and Kidney Disease in People of African Ancestry With HIV.
Sickle Cell Trait and Kidney Disease in People of African Ancestry With HIV.
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DOI：
10.1016/j.ekir.2021.12.007
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发表时间：
2022-03
影响因子：
6
通讯作者：
GEN-AFRICA Study Group
中科院分区：
文献类型：
--
作者：
Hung RKY;Binns-Roemer E;Booth JW;Hilton R;Fox J;Burns F;Harber M;Ustianowski A;Hamzah L;Burns JE;Clarke A;Price DA;Kegg S;Onyango D;Santana-Suarez B;Campbell L;Bramham K;Sharpe CC;Sabin CA;Winkler CA;Post FA;GEN-AFRICA Study Group
镰状细胞性状（SCT）与非裔美国人的慢性肾脏病（CKD）有关，尽管目前缺乏其在非洲人和艾滋病毒感染者中影响的证据。我们进行了一项横断面研究，调查SCT与英国非洲血统HIV感染者肾脏疾病之间的关系。主要结局为估计肾小球滤过率（eGFR）<60 ml/min/1.73 m2。次要结局是eGFR <90 ml/min/1.73 m2，终末期肾病（ESKD; eGFR <15 ml/min/1.73 m2，慢性透析或接受肾移植），蛋白尿（蛋白与肌酐比值>50 mg/mmol）和白蛋白尿（白蛋白与肌酐比值>3 mg/mmol）。多变量逻辑回归用于估计SCT和肾脏疾病结局之间的相关性。共纳入2895名参与者（平均年龄48.1 [SD 10.3]，57.2%为女性），其中335名（11.6%）患有SCT，352名（12.2%）eGFR <60 ml/min/1.73 m2。在调整人口统计学、HIV和肾脏风险因素（包括APOL 1高风险基因型状态）后，SCT患者更有可能eGFR <60 ml/min/1.73 m2（比值比1.62 [95%CI 1.14-2.32]），eGFR <90 ml/min/1.73 m2（1.50 [1.14-1.97]）和蛋白尿（1.50 [1.09-2.05]）。按APOL 1状态分层，在APOL 1低风险基因型患者中观察到SCT与GFR <60 ml/min/1.73 m2、eGFR <90 ml/min/1.73 m2、蛋白尿和白蛋白尿之间的显著相关性。我们的研究结果将先前报道的SCT和肾脏疾病之间的关联扩展到HIV感染者。在非洲血统的艾滋病毒感染者中，这些关联主要限于那些具有APOL 1低风险基因型的人。
Sickle cell trait (SCT) has been associated with chronic kidney disease (CKD) in African Americans, although evidence for its impact in Africans and people with HIV is currently lacking. We conducted a cross-sectional study investigating the association between SCT and kidney disease in people of African ancestry with HIV in the UK. The primary outcome was estimated glomerular filtration rate (eGFR) <60 ml/min per 1.73 m2. Secondary outcomes were eGFR <90 ml/min per 1.73 m2, end-stage kidney disease (ESKD; eGFR <15 ml/min per 1.73 m2, chronic dialysis, or having received a kidney transplant), proteinuria (protein-to-creatinine ratio >50 mg/mmol), and albuminuria (albumin-to-creatinine ratio >3 mg/mmol). Multivariable logistic regression was used to estimate the associations between SCT and kidney disease outcomes. A total of 2895 participants (mean age 48.1 [SD 10.3], 57.2% female) were included, of whom 335 (11.6%) had SCT and 352 (12.2%) had eGFR <60 ml/min per 1.73 m2. After adjusting for demographic, HIV, and kidney risk factors including APOL1 high-risk genotype status, individuals with SCT were more likely to have eGFR <60 ml/min per 1.73 m2 (odds ratio 1.62 [95% CI 1.14–2.32]), eGFR <90 ml/min per 1.73 m2 (1.50 [1.14–1.97]), and albuminuria (1.50 [1.09–2.05]). Stratified by APOL1 status, significant associations between SCT and GFR <60 ml/min per 1.73 m2, eGFR <90 ml/min per 1.73 m2, proteinuria, and albuminuria were observed for those with APOL1 low-risk genotypes. Our results extend previously reported associations between SCT and kidney disease to people with HIV. In people of African ancestry with HIV, these associations were largely restricted to those with APOL1 low-risk genotypes.
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DOI：
10.1126/science.1193032
发表时间：
2010-08-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Genovese G;Friedman DJ;Ross MD;Lecordier L;Uzureau P;Freedman BI;Bowden DW;Langefeld CD;Oleksyk TK;Uscinski Knob AL;Bernhardy AJ;Hicks PJ;Nelson GW;Vanhollebeke B;Winkler CA;Kopp JB;Pays E;Pollak MR
通讯作者：
Pollak MR
影响因子：
13.6
作者：
Kopp, Jeffrey B.;Nelson, George W.;Winkler, Cheryl A.
通讯作者：
Winkler, Cheryl A.
影响因子：
6.4
作者：
Williams, TN;Mwangi, TW;Marsh, K
通讯作者：
Marsh, K
影响因子：
6.1
作者：
Wearne, Nicola;Swanepoel, Charles R.;Rayner, Brian L.
通讯作者：
Rayner, Brian L.
影响因子：
0.9
作者：
Akinbodewa, A. A.;Ogunleye, A.;Falekulo, O. K.
通讯作者：
Falekulo, O. K.