The role of proteosome-mediated proteolysis in modulating potentially harmful transcription factor activity in Saccharomyces cerevisiae.
The role of proteosome-mediated proteolysis in modulating potentially harmful transcription factor activity in Saccharomyces cerevisiae.
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DOI：
10.1093/bioinformatics/btr211
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发表时间：
2011-07-01
期刊：
影响因子：
--
通讯作者：
Fisher J
中科院分区：
文献类型：
--
作者：
Bonzanni N;Zhang N;Oliver SG;Fisher J
Motivation: The appropriate modulation of the stress response to variable environmental conditions is necessary to maintain sustained viability in Saccharomyces cerevisiae. Particularly, controlling the abundance of proteins that may have detrimental effects on cell growth is crucial for rapid recovery from stress-induced quiescence. Results: Prompted by qualitative modeling of the nutrient starvation response in yeast, we investigated in vivo the effect of proteolysis after nutrient starvation showing that, for the Gis1 transcription factor at least, proteasome-mediated control is crucial for a rapid return to growth. Additional bioinformatics analyses show that potentially toxic transcriptional regulators have a significantly lower protein half-life, a higher fraction of unstructured regions and more potential PEST motifs than the non-detrimental ones. Furthermore, inhibiting proteasome activity tends to increase the expression of genes induced during the Environmental Stress Response more than those in the rest of the genome. Our combined results suggest that proteasome-mediated proteolysis of potentially toxic transcription factors tightly modulates the stress response in yeast. Contact: jasmin.fisher@microsoft.com Supplementary information: Supplementary data are available at Bioinformatics online.
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影响因子：
11.4
作者：
Wanke, V;Pedruzzi, I;De Virgilio, C
通讯作者：
De Virgilio, C
影响因子：
16
作者：
Pedruzzi, I;Dubouloz, F;De Virgilio, C
通讯作者：
De Virgilio, C
DOI：
10.1016/j.bbaexp.2004.08.008
发表时间：
2004-10-05
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
影响因子：
--
作者：
Dembla-Rajpal, N;Seipelt, R;Rymond, BC
通讯作者：
Rymond, BC
影响因子：
56.9
作者：
ROGERS, S;WELLS, R;RECHSTEINER, M
通讯作者：
RECHSTEINER, M
影响因子：
5.6
作者：
Ward, JJ;Sodhi, JS;Jones, DT
通讯作者：
Jones, DT