Expression of the p53 protein in a spectrum of astrocytic tumours
Expression of the p53 protein in a spectrum of astrocytic tumours
复制标题
p53 蛋白在一系列星形细胞肿瘤中的表达
作者：
D. Ellison;K. Gatter;P. Steart;D. Lane;R. Weller
Many human cancers are characterized by mutations of p53, a nuclear phosphoprotein which controls elements of the cell cycle. Turnover of p53 in normal cells is rapid, and the minute quantities of protein that are usually present are not detected by immunocytochemical methods. Mutations of the p53 gene in tumour cells are associated with a slower turnover and subsequent accumulation of the protein in both nucleus and cytoplasm. Genetic abnormalities of the short arm of chromosome 17, which is the site of the p53 gene locus, are a feature of astrocytic tumours. Usinga panel of five antibodies to p53 and a standard immunocytochemical method, we found detectable quantities of p53 in the cells of 3/16 diffuse astrocytomas, 8/14 anaplastic astrocytomas, and 24/34 glioblastoma multiforme. Progression of one patient's tumour from a diffuse to an anaplastic astrocytoma was characterized by the accumulation of p53. The more malignant histological features of anaplastic astrocytoma and glioblastoma multiforme appear to be reflected by a greater incidence of p53 accumulation.
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人类星形细胞瘤进展过程中 p53 突变和 17 号和 10 号染色体杂合性丧失。
影响因子：
11.2
作者：
Fults,D;Brockmeyer,D;Tullous,MW;Pedone,CA;Cawthon,RM
通讯作者：
Cawthon,RM
影响因子：
11.4
作者：
C. Miller;Koeffler Hp
通讯作者：
C. Miller;Koeffler Hp
影响因子：
56.9
作者：
HOLLSTEIN, M;SIDRANSKY, D;HARRIS, CC
通讯作者：
HARRIS, CC
DOI：
10.1073/pnas.84.21.7716
发表时间：
1987-11-01
影响因子：
11.1
作者：
MASUDA, H;MILLER, C;CLINE, MJ
通讯作者：
CLINE, MJ