microRNAs: key triggers of neuronal cell fate.
microRNAs: key triggers of neuronal cell fate.
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DOI：
10.3389/fncel.2014.00175
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发表时间：
2014
影响因子：
5.3
通讯作者：
Pérez-Martínez L
中科院分区：
文献类型：
--
作者：
Meza-Sosa KF;Pedraza-Alva G;Pérez-Martínez L
中枢神经系统（CNS）的发育需要一系列精确协调的事件。在胚胎发育期间，不同的细胞内和细胞外信号刺激神经干细胞成为神经祖细胞，其最终不可逆地退出细胞周期以开始神经发生的第一阶段。然而，在这一事件发生之前，神经干细胞和神经祖细胞的自我更新和增殖能力必须受到严格的调控。因此，各种进化保守的microRNA的参与是许多生物体（包括人、小鼠、鸡、青蛙和斑马鱼）的不同中枢神经系统（CNS）发育过程的关键。microRNA通过mRNAs 3′非翻译区内的序列互补性特异性识别和调节靶mRNA的表达，重要的是，单个microRNA可以有几个靶mRNA来调节一个过程;同样，一个独特的mRNA可以被多个microRNA靶向。因此，通过调节不同的靶基因，microRNA let-7、microRNA-124和microRNA-9已显示出促进神经干细胞和神经祖细胞分化成特定的神经细胞类型，而microRNA-134、microRNA-25和microRNA-137已被表征为诱导神经干细胞和神经祖细胞增殖的microRNA。本文综述了这两组microRNA的作用机制及其在神经干细胞和神经祖细胞向完全分化神经元转化过程中的功能意义。还讨论了调节这些微小RNA表达的遗传和表观遗传机制，以及最近描述的天然RNA环的作用，这些RNA环充当天然微小RNA海绵，调节神经发生早期阶段转录后微小RNA的表达和功能。
Development of the central nervous system (CNS) requires a precisely coordinated series of events. During embryonic development, different intra- and extracellular signals stimulate neural stem cells to become neural progenitors, which eventually irreversibly exit from the cell cycle to begin the first stage of neurogenesis. However, before this event occurs, the self-renewal and proliferative capacities of neural stem cells and neural progenitors must be tightly regulated. Accordingly, the participation of various evolutionary conserved microRNAs is key in distinct central nervous system (CNS) developmental processes of many organisms including human, mouse, chicken, frog, and zebrafish. microRNAs specifically recognize and regulate the expression of target mRNAs by sequence complementarity within the mRNAs 3′ untranslated region and importantly, a single microRNA can have several target mRNAs to regulate a process; likewise, a unique mRNA can be targeted by more than one microRNA. Thus, by regulating different target genes, microRNAs let-7, microRNA-124, and microRNA-9 have been shown to promote the differentiation of neural stem cells and neural progenitors into specific neural cell types while microRNA-134, microRNA-25 and microRNA-137 have been characterized as microRNAs that induce the proliferation of neural stem cells and neural progenitors. Here we review the mechanisms of action of these two sets of microRNAs and their functional implications during the transition from neural stem cells and neural progenitors to fully differentiated neurons. The genetic and epigenetic mechanisms that regulate the expression of these microRNAs as well as the role of the recently described natural RNA circles which act as natural microRNA sponges regulating post-transcriptional microRNA expression and function during the early stages of neurogenesis is also discussed.
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DOI：
10.1523/jneurosci.0558-12.2012
发表时间：
2012-06-27
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Åkerblom M;Sachdeva R;Barde I;Verp S;Gentner B;Trono D;Jakobsson J
通讯作者：
Jakobsson J
影响因子：
5.3
作者：
Davis, Tigwa H.;Cuellar, Trinna L.;Ullian, Erik M.
通讯作者：
Ullian, Erik M.
影响因子：
23.9
作者：
Delaloy C;Liu L;Lee JA;Su H;Shen F;Yang GY;Young WL;Ivey KN;Gao FB
通讯作者：
Gao FB
影响因子：
--
作者：
Bier A;Giladi N;Kronfeld N;Lee HK;Cazacu S;Finniss S;Xiang C;Poisson L;deCarvalho AC;Slavin S;Jacoby E;Yalon M;Toren A;Mikkelsen T;Brodie C
通讯作者：
Brodie C
影响因子：
4.4
作者：
Chen, Xiaoyan;Wang, Jiao;Tu, LiLi
通讯作者：
Tu, LiLi