Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development.
Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development.
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DOI:
10.1016/j.devcel.2010.04.008
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发表时间:
2010-05-18
影响因子:
11.8
通讯作者:
Kopan, Raphael
中科院分区:
文献类型:
--
作者:
Costantini, Frank;Kopan, Raphael
The two major components of the kidney, the collecting system and the nephron, have different developmental histories. The collecting system arises by the reiterated branching of a simple epithelial tube, while the nephron forms from a cloud of mesenchymal cells that coalesces into epithelial vesicles. Each develops into a morphologically complex and highly differentiated structure, and together they provide essential filtration and resorption functions. In this review we will consider their embryological origin, and the genes controlling their morphogenesis, patterning and differentiation, focusing on recent advances in several areas.
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