Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development.

Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development.
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DOI:
10.1016/j.devcel.2010.04.008
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发表时间:
2010-05-18
期刊:
影响因子:
11.8
通讯作者:
Kopan, Raphael
Kopan, Raphael
中科院分区:
生物学1区
文献类型:
--
作者:
Costantini, Frank;Kopan, Raphael

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肾脏的两个主要组成部分,收集系统和肾单位,具有不同的发育历史。集合系统由简单的上皮管的反复分支产生,而肾单位由间充质细胞云合并成上皮囊泡形成。每一个都发展成一个形态复杂和高度分化的结构,它们一起提供必要的过滤和再吸收功能。在这篇综述中,我们将考虑他们的胚胎起源,和基因控制他们的形态发生,图案和分化,集中在几个领域的最新进展。
The two major components of the kidney, the collecting system and the nephron, have different developmental histories. The collecting system arises by the reiterated branching of a simple epithelial tube, while the nephron forms from a cloud of mesenchymal cells that coalesces into epithelial vesicles. Each develops into a morphologically complex and highly differentiated structure, and together they provide essential filtration and resorption functions. In this review we will consider their embryological origin, and the genes controlling their morphogenesis, patterning and differentiation, focusing on recent advances in several areas.
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