Secretion of Pertussis Toxin from Bordetella pertussis.
Secretion of Pertussis Toxin from Bordetella pertussis.
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DOI：
10.3390/toxins13080574
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发表时间：
2021-08-18
期刊：
影响因子：
4.2
通讯作者：
Burns DL
中科院分区：
文献类型：
--
作者：
Burns DL
百日咳毒素（PT）的产生和分泌对百日咳博德泰拉的毒力至关重要。由于PT的大寡聚结构，毒素跨越细菌膜屏障的运输是细菌必须克服的一个重要障碍，以保持致病性。在分泌过程中，PT经历两步转运过程。第一步涉及PT的单个多肽链通过内膜的运输，利用广泛的分泌途径，最有可能是细菌的Sec系统。第二步是使用专门的设备将毒素运送到细菌细胞的外膜上。该装置被称为PT转运体，是PT分泌途径所特有的，是IV型细菌转运体家族的一员。本文综述了目前对PT分泌过程的理解，包括对组装形成转运体的Ptl蛋白的描述，IV型转运体的一般结构，典型IV型底物转运与Ptl介导的PT转运之间已知的异同，以及PT组装和分泌过程中已知的事件序列。
Production and secretion of pertussis toxin (PT) is essential for the virulence of Bordetella pertussis. Due to the large oligomeric structure of PT, transport of the toxin across bacterial membrane barriers represents a significant hurdle that the bacteria must overcome in order to maintain pathogenicity. During the secretion process, PT undergoes a two-step transport process. The first step involves transport of the individual polypeptide chains of PT across the inner membrane utilizing a generalized secretion pathway, most likely the bacterial Sec system. The second step involves the use of a specialized apparatus to transport the toxin across the outer membrane of the bacterial cell. This apparatus, which has been termed the Ptl transporter and which is unique to the PT secretion pathway, is a member of the type IV family of bacterial transporters. Here, the current understanding of the PT secretion process is reviewed including a description of the Ptl proteins that assemble to form the transporter, the general structure of type IV transporters, the known similarities and differences between canonical type IV substrate transport and Ptl-mediated transport of PT, as well as the known sequence of events in the assembly and secretion of PT.
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