The evolution of vertebrate somatostatin receptors and their gene regions involves extensive chromosomal rearrangements.
The evolution of vertebrate somatostatin receptors and their gene regions involves extensive chromosomal rearrangements.
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DOI：
10.1186/1471-2148-12-231
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发表时间：
2012-11-29
影响因子：
3.4
通讯作者：
Larhammar D
中科院分区：
文献类型：
--
作者：
Ocampo Daza D;Sundström G;Bergqvist CA;Larhammar D
在哺乳动物中，生长抑素及其相关神经内分泌肽具有多种生理功能，这些功能由5种名为SSTR1-5的生长抑素受体介导。为了解决SSTR基因在脊椎动物中的进化问题，我们对SSTR基因和大量相邻基因家族进行了系统发育和保守共效分析。我们发现sstr形成了两个家族，属于不同的类群。在硬骨鱼基因组中，我们不仅观察到染色体相似性反映了携带sstr染色体区域之间的相似性，而且还观察到这些区域之间的广泛重排，包括融合和易位，然后通过染色体内重排进行重组。这些事件模糊了谬误关系，但由于现在有许多基因组可用，仍然可以处理。我们发现了一种以前未被识别的SSTR亚型SSTR6，以前被错误地识别为SSTR1或SSTR4。在两个基底脊椎动物四倍体化（2R）中，有两个祖先携带ssr的染色体区域重复。这些祖先的SSTR基因之一产生SSTR2、-3和-5，另一个产生SSTR1、-4和-6。随后，SSTR6在四足动物中丢失，SSTR4在硬骨鱼中丢失。我们的研究表明，在硬骨鱼相关的染色体区域之间发生了广泛的染色体重排，但这些事件可以通过调查几个远亲物种来解决。
Somatostatin and its related neuroendocrine peptides have a wide variety of physiological functions that are mediated by five somatostatin receptors with gene names SSTR1-5 in mammals. To resolve their evolution in vertebrates we have investigated the SSTR genes and a large number of adjacent gene families by phylogeny and conserved synteny analyses in a broad range of vertebrate species. We find that the SSTRs form two families that belong to distinct paralogons. We observe not only chromosomal similarities reflecting the paralogy relationships between the SSTR-bearing chromosome regions, but also extensive rearrangements between these regions in teleost fish genomes, including fusions and translocations followed by reshuffling through intrachromosomal rearrangements. These events obscure the paralogy relationships but are still tractable thanks to the many genomes now available. We have identified a previously unrecognized SSTR subtype, SSTR6, previously misidentified as either SSTR1 or SSTR4. Two ancestral SSTR-bearing chromosome regions were duplicated in the two basal vertebrate tetraploidizations (2R). One of these ancestral SSTR genes generated SSTR2, -3 and -5, the other gave rise to SSTR1, -4 and -6. Subsequently SSTR6 was lost in tetrapods and SSTR4 in teleosts. Our study shows that extensive chromosomal rearrangements have taken place between related chromosome regions in teleosts, but that these events can be resolved by investigating several distantly related species.
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影响因子：
3.4
作者：
Larsson TA;Olsson F;Sundstrom G;Lundin LG;Brenner S;Venkatesh B;Larhammar D
通讯作者：
Larhammar D
影响因子：
4.8
作者：
Kreienkamp, HJ;Larusson, HJ;Richter, D
通讯作者：
Richter, D
影响因子：
6.5
作者：
Anisimova, Maria;Gascuel, Olivier
通讯作者：
Gascuel, Olivier
影响因子：
5.8
作者：
Larkin, M. A.;Blackshields, G.;Higgins, D. G.
通讯作者：
Higgins, D. G.
影响因子：
64.8
作者：
Kasahara, Masahiro;Naruse, Kiyoshi;Kohara, Yuji
通讯作者：
Kohara, Yuji