Rickettsia conorii entry into Vero cells
Rickettsia conorii entry into Vero cells
复制标题
康氏立克次体进入Vero细胞
作者：
N. Teysseire;J. Boudier;D. Raoult
The entry of rickettsiae into eukaryotic cells is mediated by an induced phagocytosis, but rickettsiae have never been observed in a closed phagocytic vacuole. In this study, Rickettsia conorii entry into Vero cells was observed by transmission electron microscopy during a period of 3 to 20 min after bacterium-cell contact. The entry occurred within 3 min after bacterium-cell contact, and R. conorii was observed in the process of engulfment, within a phagocytic vacuole, or free in the cytosol. Escape from the phagosome is a very rapid step since phagosome lysis was only occasionally observed. By 12 min, 90% of bacteria were internalized and half were free in the cytosol. This report confirms that rickettsiae penetrate nonphagocytic cells by induced phagocytosis and is the first demonstration of rickettsiae within a complete phagocytic vacuole.
普瓦泽基立克次体溶血羊和人红细胞中磷脂酶 A 的活性。
影响因子：
3.1
作者：
Winkler,HH;Miller,ET
通讯作者：
Miller,ET