Layer-specific functional and anatomical MRI of the retina with passband balanced SSFP.
Layer-specific functional and anatomical MRI of the retina with passband balanced SSFP.
复制标题
带有平衡SSFP的视网膜的层特异性功能和解剖学MRI。
DOI：
10.1002/mrm.22935
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发表时间：
2011-11
影响因子：
3.3
通讯作者：
Duong, Timothy Q.
中科院分区：
文献类型：
--
作者：
Muir, Eric R.;Duong, Timothy Q.
视网膜由多个细胞层和突触层组成，并由两个不同的（视网膜和脉络膜）循环滋养，这两个循环界定视网膜，并由无血管层分开。高时空分辨率，层特定的视网膜MRI仍然具有挑战性，由于磁不稳定性诱导的伪影。本研究报告了45×45×500μm和1.6s时间分辨率的通带平衡稳态自由旋进（bSSFP）MRI对小鼠视网膜成像，克服了几何失真和信号丢失，同时保持了快速采集和高信噪比。bSSFP图像显示多个交替的暗-亮-暗-亮视网膜层。低氧（10%O2）吸入减少了视网膜边界两层中的bSSFP信号，对应于视网膜和脉络膜血管。中间的层没有表现出实质性的反应，并被指定为无血管感光层。脉络膜反应（−25.9± 6.4%，平均值±SD，n=6）显著（P<0.05）大于视网膜血管反应（−11.6±2.4%）。bSSFP提供了非常高的时空分辨率，并可能在视网膜疾病的成像层特异性变化中具有重要的应用。
The retina consists of multiple cellular and synaptic layers and is nourished by two distinct (retinal and choroidal) circulations bounding the retina, separated by an avascular layer. High spatiotemporal resolution, layer-specific MRI of the retina remains challenging due to magnetic inhomogeneity-induced artifacts. This study reports passband balanced-steady-state free-precession (bSSFP) MRI at 45×45×500μm and 1.6s temporal resolution to image the mouse retina, overcoming geometric distortion and signal dropout while maintaining rapid acquisition and high signal-to-noise ratio. bSSFP images revealed multiple alternating dark-bright-dark-bright retinal layers. Hypoxic (10%O2) inhalation decreased bSSFP signals in the two layers bounding the retina, corresponding to the retinal and choroidal vasculatures. The layer in between showed no substantial response and was assigned the avascular photoreceptor layers. Choroidal responses (−25.9±6.4%, mean±SD, n=6) were significantly (P<0.05) larger than retinal vascular responses (−11.6±2.4%). bSSFP offers very high spatiotemporal resolution and could have important applications in imaging layer-specific changes in retinal diseases.
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影响因子：
4.4
作者：
Li, Yingxia;Cheng, Haiying;Duong, Timothy Q.
通讯作者：
Duong, Timothy Q.
DOI：
10.1007/bf02764305
发表时间：
1990-01-01
影响因子：
2.7
作者：
BILL, A;SPERBER, GO
通讯作者：
SPERBER, GO
影响因子：
3.3
作者：
GRUETTER, R
通讯作者：
GRUETTER, R
影响因子：
4.4
作者：
Berkowitz, Bruce A.;Roberts, Robin;Vingrys, Algis J.
通讯作者：
Vingrys, Algis J.
影响因子：
4.4
作者：
Gilmore, Edward D.;Hudson, Chris;Devenyi, Robert G.
通讯作者：
Devenyi, Robert G.