The burden of hospitalized lower respiratory tract infection due to respiratory syncytial virus in rural Thailand.
The burden of hospitalized lower respiratory tract infection due to respiratory syncytial virus in rural Thailand.
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DOI：
10.1371/journal.pone.0015098
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发表时间：
2010-11-30
期刊：
影响因子：
3.7
通讯作者：
Olsen SJ
中科院分区：
文献类型：
--
作者：
Fry AM;Chittaganpitch M;Baggett HC;Peret TC;Dare RK;Sawatwong P;Thamthitiwat S;Areerat P;Sanasuttipun W;Fischer J;Maloney SA;Erdman DD;Olsen SJ
我们描述了在泰国两个农村省份进行的基于人群的监测中所有年龄组的住院RSV感染的流行病学。从2003年9月1日至2007年12月31日，我们招募了SaKaeo和Nakhom帕诺姆省所有医院的急性下呼吸道疾病住院患者，这些患者接受了医生要求的胸片检查。我们用逆转录聚合酶链反应（RT-PCR）检测鼻咽标本中的RSV，并用IgG酶免疫测定法检测患者的配对血清。根据入组情况调整了发生率。在11，097例入组患者中，987例（8.9%）患有RSV感染。总体住院RSV感染率（和放射学证实的肺炎）在1岁以下儿童中最高：1，067/100，000（534/100，000放射学证实的肺炎）和1-4岁：403/100，000（222/100，000），但在≥65岁入组成人中较低：42/100，000。年龄<1岁（校正比值比[aOR]= 13.2，95%置信区间[CI] 7.7，22.5）和1-4岁（aOR = 8.3，95% CI 5.0，13.9）是住院RSV感染的独立预测因素。 在泰国农村，5岁以下儿童中RSV下呼吸道疾病的住院发病率较高。预防RSV感染的努力可以大大减少5岁以下儿童的肺炎负担。
We describe the epidemiology of hospitalized RSV infections for all age groups from population-based surveillance in two rural provinces in Thailand. From September 1, 2003 through December 31, 2007, we enrolled hospitalized patients with acute lower respiratory tract illness, who had a chest radiograph ordered by the physician, from all hospitals in SaKaeo and Nakhom Phanom Provinces. We tested nasopharyngeal specimens for RSV with reverse transcriptase polymerase chain reaction (RT-PCR) assays and paired-sera from a subset of patients with IgG enzyme immunoassay. Rates were adjusted for enrollment. Among 11,097 enrolled patients, 987 (8.9%) had RSV infection. Rates of hospitalized RSV infection overall (and radiographically-confirmed pneumonia) were highest among children aged <1 year: 1,067/100,000 (534/100,000 radiographically-confirmed pneumonia) and 1–4 year: 403/100,000 (222/100,000), but low among enrolled adults aged ≥65 years: 42/100,000. Age <1 year (adjusted odds ratio [aOR] = 13.2, 95% confidence interval [CI] 7.7, 22.5) and 1–4 year (aOR = 8.3, 95% CI 5.0, 13.9) were independent predictors of hospitalized RSV infection. The incidence of hospitalized RSV lower respiratory tract illness among children <5 years was high in rural Thailand. Efforts to prevent RSV infection could substantially reduce the pneumonia burden in children aged <5 years.
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影响因子：
--
作者：
Marston, BJ;Plouffe, JF;Breiman, RF
通讯作者：
Breiman, RF
DOI：
10.1056/nejmoa0804877
发表时间：
2009-02-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hall CB;Weinberg GA;Iwane MK;Blumkin AK;Edwards KM;Staat MA;Auinger P;Griffin MR;Poehling KA;Erdman D;Grijalva CG;Zhu Y;Szilagyi P
通讯作者：
Szilagyi P
影响因子：
9.4
作者：
Erdman, DD;Weinberg, GA;Anderson, LJ
通讯作者：
Anderson, LJ
影响因子：
6.4
作者：
Dowell, SF;Anderson, LJ;Breiman, RF
通讯作者：
Breiman, RF
影响因子：
5.5
作者：
Falsey, AR;Walsh, EE
通讯作者：
Walsh, EE