N-methylpurine DNA glycosylase and OGG1 DNA repair activities: opposite associations with lung cancer risk.
N-methylpurine DNA glycosylase and OGG1 DNA repair activities: opposite associations with lung cancer risk.
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DOI：
10.1093/jnci/djs445
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发表时间：
2012-11-21
期刊：
影响因子：
--
通讯作者：
Paz-Elizur T
中科院分区：
文献类型：
--
作者：
Leitner-Dagan Y;Sevilya Z;Pinchev M;Kramer R;Elinger D;Roisman LC;Rennert HS;Schechtman E;Freedman L;Rennert G;Livneh Z;Paz-Elizur T
只有少数吸烟者会患上肺癌，这可能是由于遗传易感性，包括DNA修复缺陷。为探讨N-甲基嘌呤DNA糖基化酶（MPG）DNA修复活性的个体间差异是否与肺癌相关，我们对100例肺癌患者和100例匹配的对照者进行了一项盲法、基于人群的病例对照研究，并对数据进行了条件Logistic回归分析。所有统计学检验均为双侧检验。病例组外周血单个核细胞MPG酶活性高于对照组，而8-氧代鸟嘌呤DNA糖基化酶（OGG 1）DNA修复酶活性则相反。对于MPG活性增加一个标准差的肺癌，调整后的比值比为1.8（95%置信区间[CI] = 1.2至2.6; P = 0.006）。MPG和OGG 1活性联合评分与肺癌风险的相关性比单独的MPG和OGG 1活性评分更强，比值比为2.3（95%CI = 1.4至3.6; P <0.001）。这些结果为未来肺癌风险评估和预防的风险生物标志物小组奠定了基础。
Only a minority of smokers develop lung cancer, possibly due to genetic predisposition, including DNA repair deficiencies. To examine whether inter-individual variations in DNA repair activity of N-methylpurine DNA glycosylase (MPG) are associated with lung cancer, we conducted a blinded, population-based, case–control study with 100 lung cancer case patients and 100 matched control subjects and analyzed the data with conditional logistic regression. All statistical tests were two-sided. MPG enzyme activity in peripheral blood mononuclear cells from case patients was higher than in control subjects, results opposite that of 8-oxoguanine DNA glycosylase (OGG1) DNA repair enzyme activity. For lung cancer associated with one standard deviation increase in MPG activity, the adjusted odds ratio was 1.8 (95% confidence interval [CI] = 1.2 to 2.6; P = .006). A combined MPG and OGG1 activities score was more strongly associated with lung cancer risk than either activity alone, with an odds ratio of 2.3 (95% CI = 1.4 to 3.6; P < .001). These results form a basis for a future panel of risk biomarkers for lung cancer risk assessment and prevention.
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影响因子：
16
作者：
Klapacz J;Lingaraju GM;Guo HH;Shah D;Moar-Shoshani A;Loeb LA;Samson LD
通讯作者：
Samson LD
影响因子：
3.8
作者：
Fu, Dragony;Samson, Leona D.
通讯作者：
Samson, Leona D.
影响因子：
2.9
作者：
Lee, Chun-Yue I.;Delaney, James C.;Kartalou, Maria;Lingaraju, Gondichatnahalli M.;Maor-Shoshani, Ayelet;Essigmann, John M.;Samson, Leona D.
通讯作者：
Samson, Leona D.
影响因子：
120.7
作者：
Charakida, Marietta;Besler, Christian;Deanfield, John E.
通讯作者：
Deanfield, John E.
影响因子：
13.6
作者：
RENNERT, G;TAMIR, A;EPSTEIN, L
通讯作者：
EPSTEIN, L