LncRNA-mediated posttranslational modifications and reprogramming of energy metabolism in cancer.
LncRNA-mediated posttranslational modifications and reprogramming of energy metabolism in cancer.
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LncRNA介导的癌症能量代谢的翻译后修饰和重编程。
DOI：
10.1002/cac2.12108
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Ju HQ
中科院分区：
文献类型：
--
作者：
Tan YT;Lin JF;Li T;Li JJ;Xu RH;Ju HQ
代谢改变是癌症的标志，能量代谢的重编程历来被认为是肿瘤的普遍现象。长链非编码rna （lncRNAs）在癌症中调节能量代谢，这是众所周知的。然而，lncRNA介导的翻译后修饰和代谢重编程目前尚不清楚。在这篇综述中，我们总结了目前对癌症相关能量代谢的改变与lncRNA介导的代谢酶、转录因子和其他参与代谢途径的蛋白质的翻译后修饰之间相互作用的理解。此外，我们还讨论了这些相互作用促进肿瘤发生和进展的机制，以及功能性lncrna的关键作用和临床意义。我们相信，深入了解lncRNA介导的癌症代谢重编程有助于识别可用于癌症诊断和治疗的细胞脆弱性。
Altered metabolism is a hallmark of cancer, and the reprogramming of energy metabolism has historically been considered a general phenomenon of tumors. It is well recognized that long noncoding RNAs (lncRNAs) regulate energy metabolism in cancer. However, lncRNA‐mediated posttranslational modifications and metabolic reprogramming are unclear at present. In this review, we summarized the current understanding of the interactions between the alterations in cancer‐associated energy metabolism and the lncRNA‐mediated posttranslational modifications of metabolic enzymes, transcription factors, and other proteins involved in metabolic pathways. In addition, we discuss the mechanisms through which these interactions contribute to tumor initiation and progression, and the key roles and clinical significance of functional lncRNAs. We believe that an in‐depth understanding of lncRNA‐mediated cancer metabolic reprogramming can help to identify cellular vulnerabilities that can be exploited for cancer diagnosis and therapy.
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