Neuropeptide Y-deficient mice show altered circadian response to simulated natural photoperiod.
Neuropeptide Y-deficient mice show altered circadian response to simulated natural photoperiod.
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DOI：
10.1016/j.brainres.2008.09.040
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发表时间：
2008-12-30
期刊：
影响因子：
2.9
通讯作者：
Harrington ME
中科院分区：
文献类型：
--
作者：
Kim HJ;Harrington ME
由视交叉上核(SCN)内源性产生的昼夜节律可以与各种光和非光环境刺激同步。神经肽Y(NPY)产生于膝间小叶(IGL)，对SCN既有光影响，也有非光影响。我们最近发现，当光周期从光/暗(LD)周期18：6突然改变到LD6：18时，NPY-/-小鼠的运动活动开始转移到新的光补偿时间的速度较慢。在本研究中，我们测量了NPY-/-小鼠对141天(LD16：8变为LD8：16)光周期(LD16：8改为LD8：16)逐渐变化的光周期(每天4min)的运动反应。当光周期接近LD 8：16时，NPY-/-小鼠与野生型小鼠相比，表现出显著延迟的活动开始。随着光周期的改变，活动模式分解为多个回合，活动强度降低，这些变化在NPY-/-小鼠中更加明显。我们的结果进一步支持了NPY参与昼夜夹带对季节性光周期变化的反应的观点。
Circadian rhythms, endogenously generated by the suprachiasmatic nucleus (SCN), can be synchronized to a variety of photic and non-photic environmental stimuli. Neuropeptide Y (NPY) is produced in the intergeniculate leaflet (IGL) and known to mediate both photic and non-photic influences on the SCN. We recently found that npy-/- mice were slower to shift their locomotor activity onset to the new time of light offset when photoperiod was abruptly changed from light/dark (LD) cycle 18:6 to LD 6:18. In the present study, we measured the locomotor response of npy-/- mice to gradual changes in photoperiod (4 min a day) for 141 days (LD 16:8 changing to LD 8:16), mimicking external LD cycles in nature. When the photoperiod approached LD 8:16, npy-/- mice showed a significantly delayed onset of activity compared to wild-type mice. Activity patterns disintegrated into multiple bouts and intensity of activity decreased as the photoperiod changed and these changes were more pronounced in npy-/- mice. Our results lend further support to the idea that NPY is involved in circadian entrainment responses to seasonal photoperiod changes.
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影响因子：
3.3
作者：
SHINOHARA, K;TOMINAGA, K;INOUYE, SIT
通讯作者：
INOUYE, SIT
影响因子：
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作者：
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通讯作者：
MORIN, LP
影响因子：
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作者：
Freeman, DA;Teubner, BJW;Goldman, BD
通讯作者：
Goldman, BD
DOI：
10.1152/ajpregu.00383.2006
发表时间：
2007-03-01
影响因子：
2.8
作者：
Harrington, Mary;Molyneux, Penny;Lall, Gurprit
通讯作者：
Lall, Gurprit
DOI：
10.1152/ajpregu.1997.273.6.r2132
发表时间：
1997-12-01
影响因子：
2.8
作者：
Penev, PD;Zee, PC;Turek, FW
通讯作者：
Turek, FW