Gut microbiome responds to alteration in female sex hormone status and exacerbates metabolic dysfunction.
Gut microbiome responds to alteration in female sex hormone status and exacerbates metabolic dysfunction.
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DOI：
10.1080/19490976.2023.2295429
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发表时间：
2024-01
期刊：
影响因子：
12.2
通讯作者：
中科院分区：
文献类型：
--
作者：
女性绝经后代谢功能障碍的风险显着增加，从而导致许多慢性疾病。肠道微生物组与肥胖和代谢功能障碍有关，但其与女性性激素状态的相互作用以及由此对宿主代谢的影响仍不清楚。在此，我们与性腺完整和低脂饮食对照相比，描述了与卵巢切除和高脂饮食喂养相关的炎症和代谢表型以及肠道微生物组。然后，我们使用无菌小鼠进行粪便微生物群移植（FMT），以确定卵巢切除相关的肠道微生物组对炎症和代谢结果的影响。我们证明，卵巢切除术会导致胃肠道通透性增加以及肠道和代谢器官的炎症，而高脂肪饮食会加剧这些表型。卵巢切除术还导致肠道微生物群的改变，包括粪便 β-葡萄糖醛酸酶活性的增加。然而，肠道微生物群的差异变化仅在低脂饮食时才会发生，而在高脂饮食时则不会。与接受完整假对照相关微生物组的小鼠相比，接受低脂饮食喂养的卵巢切除小鼠的肠道微生物组的知生小鼠体重增加更大，并且与代谢功能障碍和炎症相关的肝脏基因表达更大。这些结果表明肠道微生物群对女性性激素状态的变化做出反应并导致代谢功能障碍。识别和开发针对肠道微生物组的调节剂来调节性激素可能有助于治疗更年期相关疾病。
Women are at significantly greater risk of metabolic dysfunction after menopause, which subsequently leads to numerous chronic illnesses. The gut microbiome is associated with obesity and metabolic dysfunction, but its interaction with female sex hormone status and the resulting impact on host metabolism remains unclear. Herein, we characterized inflammatory and metabolic phenotypes as well as the gut microbiome associated with ovariectomy and high-fat diet feeding, compared to gonadal intact and low-fat diet controls. We then performed fecal microbiota transplantation (FMT) using gnotobiotic mice to identify the impact of ovariectomy-associated gut microbiome on inflammatory and metabolic outcomes. We demonstrated that ovariectomy led to greater gastrointestinal permeability and inflammation of the gut and metabolic organs, and that a high-fat diet exacerbated these phenotypes. Ovariectomy also led to alteration of the gut microbiome, including greater fecal β-glucuronidase activity. However, differential changes in the gut microbiome only occurred when fed a low-fat diet, not the high-fat diet. Gnotobiotic mice that received the gut microbiome from ovariectomized mice fed the low-fat diet had greater weight gain and hepatic gene expression related to metabolic dysfunction and inflammation than those that received intact sham control-associated microbiome. These results indicate that the gut microbiome responds to alterations in female sex hormone status and contributes to metabolic dysfunction. Identifying and developing gut microbiome-targeted modulators to regulate sex hormones may be useful therapeutically in remediating menopause-related diseases.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
--
作者：
Khalili L;Alipour B;Asghari Jafar-Abadi M;Faraji I;Hassanalilou T;Mesgari Abbasi M;Vaghef-Mehrabany E;Alizadeh Sani M
通讯作者：
Alizadeh Sani M
DOI：
10.1038/ismej.2012.8
发表时间：
2012-08
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
--
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
大豆改善女性低拟合大鼠的心脏代谢健康和盲肠微生物群。
影响因子：
4.6
作者：
Cross TL;Zidon TM;Welly RJ;Park YM;Britton SL;Koch LG;Rottinghaus GE;de Godoy MRC;Padilla J;Swanson KS;Vieira-Potter VJ
通讯作者：
Vieira-Potter VJ