A systematic review of cognitive function in first-episode psychosis, including a discussion on childhood trauma, stress, and inflammation.
A systematic review of cognitive function in first-episode psychosis, including a discussion on childhood trauma, stress, and inflammation.
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DOI：
10.3389/fpsyt.2013.00182
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发表时间：
2014-01-08
影响因子：
4.7
通讯作者：
Pariante CM
中科院分区：
文献类型：
--
作者：
Aas M;Dazzan P;Mondelli V;Melle I;Murray RM;Pariante CM
目的：对首发精神病（FEP）认知功能的相关文献进行系统综述。虽然这不是一个完整的“精神分裂症的认知遗传学回顾”，但我们也将包括这些损伤背后的假设机制，重点关注早期压力和遗传脆弱性如何调节精神病患者的认知功能。方法：通过计算机文献检索检索到2013年1月及之前发表的相关研究，仅纳入病例对照研究进行神经认知meta分析。结果：与健康对照相比，FEP患者存在整体认知障碍。最大的效应量是文字记忆（Cohen效应量= 2.10），其次是执行功能（效应量= 1.86）和一般智商（效应量= 1.71）。然而，不同研究的效应大小各不相同。结论：在FEP研究中已经出现了跨领域的认知障碍，根据Cohen效应大小，认知障碍达到了严重程度。然而，在研究之间以及在领域内观察到损伤水平的差异，表明在疾病过程中可能存在认知损伤的进一步巩固。认知异常可能与神经发育模型有关，包括对压力负面影响的敏感性增加，以及遗传脆弱性。在这个领域需要更多的研究。
Objective: To carry out a systematic review of the literature addressing cognitive functions in first-episode psychosis (FEP), divided into domains. Although this is not a full “cognitive-genetics-in-schizophrenia review,” we will also include putative ideas of mechanism(s) behind these impairments, focusing on how early stress, and genetic vulnerability may moderate cognitive function in psychosis. Method: Relevant studies were identified via computer literature searches for research published up to and including January 2013, only case-control studies were included for the neurocognitive meta-analysis. Results: Patients with FEP present global cognitive impairment compared to healthy controls. The largest effect size was observed for verbal memory (Cohen’s d effect size = 2.10), followed by executive function (effect size = 1.86), and general IQ (effect size = 1.71). However, effect sizes varied between studies. Conclusion: Cognitive impairment across domains, up to severe level based on Cohen’s effect size, is present already in FEP studies. However, differences in levels of impairment are observed between studies, as well as within domains, indicating that further consolidation of cognitive impairment over the course of illness may be present. Cognitive abnormalities may be linked to a neurodevelopmental model including increased sensitivity to the negative effect of stress, as well as genetic vulnerability. More research on this field is needed.
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影响因子：
4.5
作者：
Addington, J;Brooks, BL;Addington, D
通讯作者：
Addington, D
影响因子：
4.5
作者：
Buckley, Peter F.;Pillai, Anilkumar;Mahadik, Sahebarao
通讯作者：
Mahadik, Sahebarao
DOI：
10.1038/npp.2008.107
发表时间：
2009-03
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1016/0887-6177(90)90024-j
发表时间：
1990-01-01
期刊：
Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
影响因子：
--
作者：
Goldstein, G
通讯作者：
Goldstein, G
影响因子：
6.6
作者：
Fisher, Helen L.;Craig, Thomas K.;Morgan, Craig
通讯作者：
Morgan, Craig