Chitosan/Polyvinyl Alcohol/Tea Tree Essential Oil Composite Films for Biomedical Applications.
Chitosan/Polyvinyl Alcohol/Tea Tree Essential Oil Composite Films for Biomedical Applications.
复制标题
用于生物医学应用的壳聚糖/聚乙烯醇/茶树精油复合膜。
DOI：
10.3390/polym13213753
复制
发表时间：
2021-10-29
期刊：
影响因子：
5
通讯作者：
Grande-Tovar CD
中科院分区：
文献类型：
--
作者：
Castro JI;Valencia-Llano CH;Valencia Zapata ME;Restrepo YJ;Mina Hernandez JH;Navia-Porras DP;Valencia Y;Valencia C;Grande-Tovar CD
组织工程是至关重要的，因为它的早期采用集中在设计生物相容性材料，刺激细胞粘附和增殖。从这个意义上说，由生物相容性和耐受性材料制成的支架成为研究人员在生物医学应用中的重点。人类已经使用精油很长一段时间，以利用其抗真菌，杀虫剂，抗菌和抗氧化特性。然而，文献证明使用精油刺激新支架设计的生物相容性是稀缺的。为此，本工作描述了壳聚糖/聚乙烯醇/茶树（互叶白千层），精油（CS/PVA/TTEO）的四种不同的膜复合材料的合成，并在Wistar大鼠皮下注射90天后。根据杨氏模量、DSC、TGA、力学研究和热研究，TTEO的加入具有增强效果。浸泡在模拟体液（SBF）中后的形态和能量色散（EDX）分析显示，在材料表面上产生了一层氯化钙和氯化钠的薄层，这通常与生物活性材料有关。最后，膜的生物相容性与猪胶原相当，随着TTEO量的增加，显示出更好的再吸收迹象。这些结果表明，在长期的生物医学需求的膜的潜在应用。
Tissue engineering is crucial, since its early adoption focused on designing biocompatible materials that stimulate cell adhesion and proliferation. In this sense, scaffolds made of biocompatible and resistant materials became the researchers’ focus on biomedical applications. Humans have used essential oils for a long time to take advantage of their antifungal, insecticide, antibacterial, and antioxidant properties. However, the literature demonstrating the use of essential oils for stimulating biocompatibility in new scaffold designs is scarce. For that reason, this work describes the synthesis of four different film composites of chitosan/polyvinyl alcohol/tea tree (Melaleuca alternifolia), essential oil (CS/PVA/TTEO), and the subdermal implantations after 90 days in Wistar rats. According to the Young modulus, DSC, TGA, mechanical studies, and thermal studies, there was a reinforcement effect with the addition of TTEO. Morphology and energy-dispersive (EDX) analysis after the immersion in simulated body fluid (SBF) exhibited a light layer of calcium chloride and sodium chloride generated on the material’s surface, which is generally related to a bioactive material. Finally, the biocompatibility of the films was comparable with porcine collagen, showing better signs of resorption as the amount of TTEO was increased. These results indicate the potential application of the films in long-term biomedical needs.
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DOI：
10.1590/1678-775720160044
发表时间：
2016-11
期刊：
Journal of applied oral science : revista FOB
影响因子：
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作者：
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发表时间：
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影响因子：
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