Relationship of serum adiponectin and resistin levels with breast cancer risk.
Relationship of serum adiponectin and resistin levels with breast cancer risk.
复制标题
DOI：
10.3346/jkms.2007.22.1.117
复制
发表时间：
2007-02
影响因子：
4.5
通讯作者：
Youn DS
中科院分区：
文献类型：
--
作者：
Kang JH;Yu BY;Youn DS
肥胖是乳腺癌的常见危险因素之一。我们评估了41例经活检证实的乳腺癌患者和43例年龄和体重指数匹配的对照者的血清脂联素和脂联素水平与乳腺癌风险之间的关系。乳腺癌组的平均血清脂联素水平低于对照组（6.93±3.2 µg/mL vs. 7.60±3.5 µg/mL），但该差异未达到统计学显著性（p=0.37）。两组之间的血清Glucagon水平存在统计学显著差异（乳腺癌组5.23±6.9 ng/mL对比对照组1.46±2.0 ng/mL; p<0.001）。与最低三分位组相比，血清β-内酰胺酶水平最高三分位组的乳腺癌风险显著增加（校正比值比2.77 [95%CI 1.40-5.50]）。脂联素水平低于中位值的患者淋巴结转移显著增加（p=0.017）。在患者中，其β-内酰胺酶水平高于中位数，具有最高组织学分级的肿瘤的频率显著增加（p=0.025）。总之，低血清脂联素水平和高血清脂联素水平可能与韩国妇女乳腺癌风险增加有关。
Obesity is one of the well-known risk factors of breast cancer. We evaluated the relationship between serum adiponectin and resistin levels and breast cancer risk in 41 biopsy-proven breast cancer patients and 43 age- and body mass index-matched controls. The mean serum adiponectin level was lower in the breast cancer group than the control group (6.93±3.2 µg/mL, vs. 7.60±3.5 µg/mL), but this difference did not reach statistical significance (p=0.37). There was a statistically significant difference in serum resistin levels between the groups (breast cancer group 5.23±6.9 ng/mL vs. control 1.46±2.0 ng/mL; p<0.001). The risk of breast cancer was significantly increased in the highest tertile group for serum resistin level compared to the lowest tertile group (adjusted odds ratio 2.77 [95% CI 1.40-5.50]). The lymph node metastasis was significantly increased in the patients with less than the median adiponectin level (p=0.017). In the patients whose resistin level was higher than the median, the frequency of tumor with the highest histological grade was significantly increased (p=0.025). In conclusions, both the low serum adiponectin levels and high resistin levels are likely to be associated with increased breast cancer risk in Korean women.
登录
查看更多内容
影响因子：
37.8
作者：
Okamoto, Y;Kihara, S;Matsuzawa, Y
通讯作者：
Matsuzawa, Y
影响因子：
5.8
作者：
Dal Maso, L;Augustin, LSA;La Vecchia, C
通讯作者：
La Vecchia, C
影响因子：
10.3
作者：
Wei, EK;Giovannucci, E;Mantzoros, CS
通讯作者：
Mantzoros, CS
DOI：
10.1046/j.1467-789x.2003.00108.x
发表时间：
2003-08-01
期刊：
Obesity reviews : an official journal of the International Association for the Study of Obesity
影响因子：
--
作者：
Harvie, M;Hooper, L;Howell, A H
通讯作者：
Howell, A H
影响因子：
5.8
作者：
Weyer, C;Funahashi, T;Tataranni, PA
通讯作者：
Tataranni, PA