Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants.
Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants.
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DOI：
10.1016/j.cell.2022.03.019
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发表时间：
2022-04-28
期刊：
影响因子：
64.5
通讯作者：
Chiu CY
中科院分区：
文献类型：
--
作者：
Servellita V;Syed AM;Morris MK;Brazer N;Saldhi P;Garcia-Knight M;Sreekumar B;Khalid MM;Ciling A;Chen PY;Kumar GR;Gliwa AS;Nguyen J;Sotomayor-Gonzalez A;Zhang Y;Frias E;Prostko J;Hackett J Jr;Andino R;Wadford DA;Hanson C;Doudna J;Ott M;Chiu CY
使用病毒样颗粒（VLP）和活病毒检测来研究来自128名接种个体的259份样本中对Delta和Omicron SARS-CoV-2变体的中和免疫。Delta突破感染后，与未感染的加强和未加强个体相比，抗WT滴度分别升高57倍和3.1倍，而Omicron突破感染仅升高5.8倍和降低3.1倍。在免疫活性的未加强免疫的患者中，Delta突破性感染诱导的抗WT滴度是Omicron的10.8倍（p = 0.037）。Omicron突破性感染相对于Delta的抗体应答降低可能与无症状或轻度突破性感染的比例较高（分别为55.0%和28.6%）相关，与中度至重度感染相比，无症状或轻度突破性感染显示抗WT滴度低12.3倍（p = 0.020）。在Delta或Omicron突破感染后，观察到有限的变体特异性交叉中和免疫。这些结果表明，Omicron突破性感染的免疫原性低于Delta，因此对再感染或未来变体感染的保护作用降低。在比较SARS-CoV-2 Delta和Omicron变体的突破性感染时，后者虽然比Delta感染温和，但与较低的抗体滴度和有限的交叉中和免疫相关，这表明对再感染或未来变体感染的保护作用降低。
Virus-like particle (VLP) and live virus assays were used to investigate neutralizing immunity against Delta and Omicron SARS-CoV-2 variants in 259 samples from 128 vaccinated individuals. Following Delta breakthrough infection, titers against WT rose 57-fold and 3.1-fold compared with uninfected boosted and unboosted individuals, respectively, versus only a 5.8-fold increase and 3.1-fold decrease for Omicron breakthrough infection. Among immunocompetent, unboosted patients, Delta breakthrough infections induced 10.8-fold higher titers against WT compared with Omicron (p = 0.037). Decreased antibody responses in Omicron breakthrough infections relative to Delta were potentially related to a higher proportion of asymptomatic or mild breakthrough infections (55.0% versus 28.6%, respectively), which exhibited 12.3-fold lower titers against WT compared with moderate to severe infections (p = 0.020). Following either Delta or Omicron breakthrough infection, limited variant-specific cross-neutralizing immunity was observed. These results suggest that Omicron breakthrough infections are less immunogenic than Delta, thus providing reduced protection against reinfection or infection from future variants. In comparing breakthrough infections from the SARS-CoV-2 Delta and Omicron variants, the latter, though milder than Delta infections, were associated with lower antibody titers and limited cross-neutralizing immunity, suggesting reduced protection against reinfection or infection from a future variant.
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DOI：
10.1016/s0140-6736(22)00017-4
发表时间：
2022-01-29
期刊：
Lancet (London, England)
影响因子：
--
作者：
Wolter N;Jassat W;Walaza S;Welch R;Moultrie H;Groome M;Amoako DG;Everatt J;Bhiman JN;Scheepers C;Tebeila N;Chiwandire N;du Plessis M;Govender N;Ismail A;Glass A;Mlisana K;Stevens W;Treurnicht FK;Makatini Z;Hsiao NY;Parboosing R;Wadula J;Hussey H;Davies MA;Boulle A;von Gottberg A;Cohen C
通讯作者：
Cohen C
DOI：
10.1038/s41577-022-00676-6
发表时间：
2022-03
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Flemming A
通讯作者：
Flemming A
DOI：
10.1101/2021.08.09.21261290
发表时间：
2022-01-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gilbert, Peter B;Montefiori, David C;Koup, Richard A
通讯作者：
Koup, Richard A
影响因子：
30.3
作者：
Case, James Brett;Rothlauf, Paul W.;Whelan, Sean P. J.
通讯作者：
Whelan, Sean P. J.
影响因子：
82.9
作者：
Gruell H;Vanshylla K;Tober-Lau P;Hillus D;Schommers P;Lehmann C;Kurth F;Sander LE;Klein F
通讯作者：
Klein F