Poised Regeneration of Zebrafish Melanocytes Involves Direct Differentiation and Concurrent Replenishment of Tissue-Resident Progenitor Cells.
Poised Regeneration of Zebrafish Melanocytes Involves Direct Differentiation and Concurrent Replenishment of Tissue-Resident Progenitor Cells.
复制标题
斑马鱼黑素细胞的固执再生涉及直接分化和同时补充组织居民祖细胞。
DOI：
10.1016/j.devcel.2015.04.025
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发表时间：
2015-06-22
影响因子：
11.8
通讯作者：
Ceol, Craig J.
中科院分区：
文献类型：
--
作者：
Iyengar, Sharanya;Kasheta, Melissa;Ceol, Craig J.
损伤后的有效再生对于维持组织功能和使生物体存活至关重要。重建受损组织的细胞通常由常驻干细胞或祖细胞或由已去分化并变得增殖的细胞产生。虽然谱系追踪研究已经定义了许多组织中再生的细胞来源，但这些细胞执行再生过程的过程在很大程度上尚不清楚。在这里，我们已经确定了组织驻留祖细胞介导斑马鱼条纹黑素细胞的再生，并确定这些细胞如何重建色素沉着。几乎所有再生黑素细胞都是通过祖细胞的直接分化产生的。Wnt信号传导在分化之前被激活，并且Wnt信号传导的抑制损害再生。额外的祖细胞对称分裂以维持祖细胞库。将直接分化与对称的祖细胞分裂相结合，可以作为一种快速修复受损组织同时保持再生能力的手段。
Efficient regeneration following injury is critical for maintaining tissue function and enabling organismal survival. Cells reconstituting damaged tissue are often generated from resident stem or progenitor cells or from cells that have dedifferentiated and become proliferative. While lineage-tracing studies have defined cellular sources of regeneration in many tissues, the process by which these cells execute the regenerative process is largely obscure. Here, we have identified tissue-resident progenitor cells that mediate regeneration of zebrafish stripe melanocytes and defined how these cells reconstitute pigmentation. Nearly all regeneration melanocytes arise through direct differentiation of progenitor cells. Wnt signaling is activated prior to differentiation, and inhibition of Wnt signaling impairs regeneration. Additional progenitors divide symmetrically to sustain the pool of progenitor cells. Combining direct differentiation with symmetric progenitor divisions may serve as a means to rapidly repair injured tissue while preserving the capacity to regenerate.
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影响因子：
2.7
作者：
Dorsky, RI;Sheldahl, LC;Moon, RT
通讯作者：
Moon, RT
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通讯作者：
Lum, Lawrence