Staying true to yourself: mechanisms of DNA methylation maintenance in mammals.
Staying true to yourself: mechanisms of DNA methylation maintenance in mammals.
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DOI：
10.1093/nar/gkaa1154
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发表时间：
2021-04-06
影响因子：
14.9
通讯作者：
Defossez PA
中科院分区：
文献类型：
--
作者：
Petryk N;Bultmann S;Bartke T;Defossez PA
DNA甲基化对哺乳动物的发育和细胞生理至关重要。在人类疾病如癌症和神经系统疾病中经常观察到fauclidDNA甲基化。在分子上，这种表观遗传标记与其他染色质修饰相关，并调节关键的基因组过程，包括转录和剪接。每一轮DNA复制都会产生两个半甲基化的基因组拷贝。这些必须在下一个S期之前转换回对称甲基化的DNA，否则标记将消失;因此DNA甲基化的维持是必不可少的。从机制上讲，这种表观遗传修饰的维持发生在DNA复制期间和之后，并且发生在染色质重新组装的非常动态的背景下。在这里，我们回顾了最近的发现和未解决的问题，在哺乳动物中的DNA甲基化维持的机制，动力学和保真度。我们还讨论了它是如何在正常发育中被调节和在疾病中被错误调节的。
DNA methylation is essential to development and cellular physiology in mammals. Faulty DNA methylation is frequently observed in human diseases like cancer and neurological disorders. Molecularly, this epigenetic mark is linked to other chromatin modifications and it regulates key genomic processes, including transcription and splicing. Each round of DNA replication generates two hemi-methylated copies of the genome. These must be converted back to symmetrically methylated DNA before the next S-phase, or the mark will fade away; therefore the maintenance of DNA methylation is essential. Mechanistically, the maintenance of this epigenetic modification takes place during and after DNA replication, and occurs within the very dynamic context of chromatin re-assembly. Here, we review recent discoveries and unresolved questions regarding the mechanisms, dynamics and fidelity of DNA methylation maintenance in mammals. We also discuss how it could be regulated in normal development and misregulated in disease.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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