Photo-damage mechanisms and anti-apoptotic effect of lutein in the mouse retina
Photo-damage mechanisms and anti-apoptotic effect of lutein in the mouse retina
复制标题
叶黄素对小鼠视网膜的光损伤机制及抗凋亡作用
DOI：
10.2492/inflammregen.32.208
复制
发表时间：
2012
影响因子：
8.1
通讯作者：
Y. Ozawa
中科院分区：
文献类型：
--
作者：
Seiji Miyake;M. Sasaki;N. Takahashi;K. Tsubota;Y. Ozawa
光感受器细胞接收光并将其转换为电信号以进行视觉感知。然而，过度暴露于可见光会导致感光细胞发生凋亡，这被称为光损伤。这种损伤涉及几种生化事件，包括氧化应激的积累和细胞内钙和一氧化氮（NO）的升高。光损伤被认为与视网膜色素变性和年龄相关性黄斑变性的进展有关。因此，了解视网膜光损伤的分子机制，使用模型动物可能会导致新的治疗方法，以防止这些眼部疾病的进展。本文综述了近年来有关光诱导视网膜损伤机制的研究进展，并简要介绍了叶黄素对小鼠视网膜光损伤的干预作用。叶黄素从食物中摄取，并全身性地传递到视网膜、皮肤和某些器官和组织。它降低活性氧的水平，并在光暴露小鼠的视网膜中作为抗氧化剂，最终防止光诱导的DNA双链断裂和细胞凋亡。虽然还需要进一步的研究，叶黄素可能被提出作为一种新的治疗方法，用于预防人类的光损伤。Rec.3/29/2012，Acc.5/17/2012，pp.208 -212
Photoreceptor cells receive light and transduce it to electrical signals for visual perception. However, excessive exposure to visible light causes photoreceptor cells to undergo apoptosis, which is called photo-damage. This damage involves several biochemical events, including the accumulation of oxidative stress and the elevation of intracellular calcium and nitric oxide (NO). Photo-damage is thought to be related to the progression of retinitis pigmentosa and age-related macular degeneration. Therefore, understanding the molecular mechanisms of retinal photodamage using model animals may lead to new therapeutic approaches for preventing the progression of these ocular diseases. In this review, we summarize previous reports examining the mechanisms of light-induced retinal damage, and briefly describe the interventional effect of lutein against photo-damage in mice. Lutein is taken from food and systemically delivered to the retina, skin, and certain organs and tissues. It reduces the level of reactive oxygen species and acts as an anti-oxidant in the retina of light-exposed mice, ultimately preventing light-induced DNA double-strand breaks and apoptosis. Although further study is required, lutein may be proposed as a new therapeutic approach for preventing photo-damage in humans. Rec.3/29/2012, Acc.5/17/2012, pp208-212
登录
查看更多内容
c-fos-/- 小鼠的视网膜：电生理学、形态学和生化方面。
DOI：
--
发表时间：
2000
期刊：
Investigative ophthalmology & visual science.
影响因子：
--
作者：
Kueng-Hitz,N;Grimm,C;Lansel,N;Hafezi,F;He,L;Fox,DA;Reme,CE;Niemeyer,G;Wenzel,A
通讯作者：
Wenzel,A
人、小鼠和牛顺式视黄醇脱氢酶的底物特异性和 13-顺式视黄酸抑制。
DOI：
10.1016/s0167-4838(99)00232-0
发表时间：
2000
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Gamble,MV;Mata,NL;Tsin,AT;Mertz,JR;Blaner,WS
通讯作者：
Blaner,WS
影响因子：
7.4
作者：
Zhao, HT;Kalivendi, S;Kalyanaraman, B
通讯作者：
Kalyanaraman, B
影响因子：
4.4
作者：
J. C. Saari
通讯作者：
J. C. Saari
DOI：
10.1016/0006-291x(89)92674-0
发表时间：
1989
影响因子：
3.1
作者：
Law,WC;Rando,RR
通讯作者：
Rando,RR