Role of β-catenin/TCF-4 signaling in HIV replication and pathogenesis: insights to informing novel anti-HIV molecular therapeutics.

Role of β-catenin/TCF-4 signaling in HIV replication and pathogenesis: insights to informing novel anti-HIV molecular therapeutics.
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DOI:
10.1007/s11481-011-9266-7
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发表时间:
2011-06
影响因子:
6.2
通讯作者:
Al-Harthi, Lena
Al-Harthi, Lena
中科院分区:
医学3区
文献类型:
--
作者:
Henderson, Lisa J.;Al-Harthi, Lena

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A greater understanding of the interaction between HIV and host signaling pathways that restrict virus production may lead to new methods to purge virus from latent reservoirs and enhance survival/function of cells targeted by HIV. This review highlights the role of the Wnt/β-catenin pathway as a host factor that represses HIV replication in multiple targets, especially those relevant to HIV in the central nervous system.
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