Transfer RNA-derived small RNAs: potential applications as novel biomarkers for disease diagnosis and prognosis.
Transfer RNA-derived small RNAs: potential applications as novel biomarkers for disease diagnosis and prognosis.
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转移 RNA 衍生的小 RNA：作为疾病诊断和预后的新型生物标志物的潜在应用。
DOI：
10.21037/atm-20-2797
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发表时间：
2020-09
影响因子：
--
通讯作者：
Zhou Y
中科院分区：
文献类型：
--
作者：
Jia Y;Tan W;Zhou Y
S是一种新的非编码RNA，在多种组织和器官中表达。已报道的tsRNAs有两种亚型：tRNA衍生的应激诱导RNA(TiRNA)S和tRNA衍生片段(TRNAs)S。据报道，tsRNAs在多种生理活动中发挥着重要的作用并具有不同的生物学功能。近年来，tsRNAs与多种疾病密切相关，如癌症(包括乳腺癌、卵巢癌、肺癌、前列腺癌、结直肠癌等)、神经系统疾病、病毒感染、代谢性疾病和血管生成相关疾病等。虽然tsRNAs的生物学功能仍不清楚，但最近已有报道称，tsRNA表达异常与疾病发生发展之间的相关性。此外，它们作为潜在的疾病诊断和预后生物标志物的能力已经在临床研究中被揭示出来。本文综述了tsRNAs的研究现状，并讨论了tsRNAs作为生物标志物在不同疾病中的潜在临床应用。尽管tsRNAs的调控在相关的生理和病理过程中与miRNAs相似，但tsRNAs的较高稳定性和表达水平使其成为癌症和其他疾病诊断和预后的理想生物标志物。因此，这些已报道的tsRNAs作为临床应用于疾病诊断和预后的潜在生物标志物的可能性和可靠性值得验证。
Transfer RNA-derived small RNA (tsRNA)s are novel non-coding RNAs, expressed in a variety of tissues and organs. Two subtypes of tsRNAs have been reported: tRNA-derived stress-induced RNA (tiRNA)s and tRNA-derived fragment (tRF)s. tsRNAs have been reported to play essential roles and possess different biological functions in a variety of physiological activities. Recently, tsRNAs have been implicated in a large number of diseases, such as cancers (including breast cancer, ovarian cancer, lung cancer, prostate cancer, colorectal cancer, etc.), neurological disorders, viral infections, metabolic diseases and angiogenesis-related diseases. Although the biological functions of tsRNAs are still poorly understood, correlations between dysregulated tsRNA expression and disease development have been recently reported. Additionally, their capabilities as potential biomarkers for disease diagnosis and prognosis have been revealed in clinical studies. In this review, we summarize the current knowledge of tsRNAs, and discuss their potential clinical applications as biomarkers in different diseases. Although the regulation of tsRNAs is similar to miRNAs in regards to the related physiological and pathological processes, the higher stability and expression levels of tsRNAs place them as ideal biomarkers for the diagnosis and prognosis in cancer and other diseases. Therefore, it is worth to verify the possibility and reliability of these reported tsRNAs as potential biomarkers for clinical applications in disease diagnosis and prognosis.
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影响因子：
64.5
作者：
Carone BR;Fauquier L;Habib N;Shea JM;Hart CE;Li R;Bock C;Li C;Gu H;Zamore PD;Meissner A;Weng Z;Hofmann HA;Friedman N;Rando OJ
通讯作者：
Rando OJ
DOI：
10.4137/bic.s20764
发表时间：
2014
期刊：
Biomarkers in cancer
影响因子：
--
作者：
Dhahbi JM;Spindler SR;Atamna H;Boffelli D;Martin DI
通讯作者：
Martin DI
影响因子：
4.6
作者：
Bradshaw WJ;Rehman S;Pham TT;Thiyagarajan N;Lee RL;Subramanian V;Acharya KR
通讯作者：
Acharya KR
影响因子：
64.5
作者：
Goodarzi H;Liu X;Nguyen HC;Zhang S;Fish L;Tavazoie SF
通讯作者：
Tavazoie SF
DOI：
10.1261/rna.058834.116
发表时间：
2017-02
期刊：
RNA (New York, N.Y.)
影响因子：
--
作者：
Khurana R;Ranches G;Schafferer S;Lukasser M;Rudnicki M;Mayer G;Hüttenhofer A
通讯作者：
Hüttenhofer A