Cancer stem cells in glioblastoma.
Cancer stem cells in glioblastoma.
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DOI：
10.1101/gad.261982.115
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发表时间：
2015-06-15
影响因子：
10.5
通讯作者：
Rich JN
中科院分区：
文献类型：
--
作者：
Lathia JD;Mack SC;Mulkearns-Hubert EE;Valentim CL;Rich JN
胶质母细胞瘤是最普遍和恶性的原发性脑肿瘤，含有有助于肿瘤起始和治疗抗性的自我更新的致瘤性癌症干细胞（CSC）。在这篇综述中，Lathia等人讨论了遗传学，表观遗传学和代谢的整合如何塑造了我们对CSC如何发挥作用以驱动GBM生长的理解。在发育和体内平衡中具有明确细胞层次的组织产生具有细胞层次的肿瘤，这表明肿瘤重演特定组织并模仿其起源。胶质母细胞瘤（GBM）是最普遍和恶性的原发性脑肿瘤，并且含有有助于肿瘤起始和治疗抗性的自我更新的致瘤性癌症干细胞（CSC）。由于正常的干细胞和祖细胞参与组织发育和修复，这些发育程序重新出现在CSC中，以支持肿瘤的发育和进行性生长。阐明控制CSC的分子机制为GBM和其他脑癌的新型靶向治疗药物的开发提供了信息。CSC不是自我自治的单位;相反，它们在生态系统中发挥作用，积极重塑微环境，并从其生态位中接收关键的维护线索。为了实现开发新疗法以瓦解CSC动力学的未来目标，与其他与其微环境高度互动并使用发育信号通路的正常和病理状态进行比较将是有益的。
Glioblastoma is the most prevalent and malignant primary brain tumor, containing self-renewing, tumorigenic cancer stem cells (CSCs) that contribute to tumor initiation and therapeutic resistance. In this review, Lathia et al. discuss how the integration of genetics, epigenetics, and metabolism has shaped our understanding of how CSCs function to drive GBM growth. Tissues with defined cellular hierarchies in development and homeostasis give rise to tumors with cellular hierarchies, suggesting that tumors recapitulate specific tissues and mimic their origins. Glioblastoma (GBM) is the most prevalent and malignant primary brain tumor and contains self-renewing, tumorigenic cancer stem cells (CSCs) that contribute to tumor initiation and therapeutic resistance. As normal stem and progenitor cells participate in tissue development and repair, these developmental programs re-emerge in CSCs to support the development and progressive growth of tumors. Elucidation of the molecular mechanisms that govern CSCs has informed the development of novel targeted therapeutics for GBM and other brain cancers. CSCs are not self-autonomous units; rather, they function within an ecological system, both actively remodeling the microenvironment and receiving critical maintenance cues from their niches. To fulfill the future goal of developing novel therapies to collapse CSC dynamics, drawing parallels to other normal and pathological states that are highly interactive with their microenvironments and that use developmental signaling pathways will be beneficial.
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DOI：
10.1186/1748-717x-8-65
发表时间：
2013-03-19
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
Barazzuol L;Jena R;Burnet NG;Meira LB;Jeynes JC;Kirkby KJ;Kirkby NF
通讯作者：
Kirkby NF
影响因子：
11.2
作者：
Bonavia R;Inda MM;Cavenee WK;Furnari FB
通讯作者：
Furnari FB
影响因子：
5.2
作者：
Bar, Eli E.;Chaudhry, Aneeka;Eberharta, Charles G.
通讯作者：
Eberharta, Charles G.
影响因子：
50.3
作者：
Binda E;Visioli A;Giani F;Lamorte G;Copetti M;Pitter KL;Huse JT;Cajola L;Zanetti N;DiMeco F;De Filippis L;Mangiola A;Maira G;Anile C;De Bonis P;Reynolds BA;Pasquale EB;Vescovi AL
通讯作者：
Vescovi AL
影响因子：
64.8
作者：
Chang, Hannah H.;Hemberg, Martin;Huang, Sui
通讯作者：
Huang, Sui