Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa.
Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa.
复制标题
2014-2015年西非埃博拉病毒疫情时空分析。
DOI：
10.1038/nature14594
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发表时间：
2015-08-06
期刊：
影响因子：
64.8
通讯作者：
Guenther, Stephan
中科院分区：
文献类型：
--
作者：
Carroll, Miles W.;Matthews, David A.;Hiscox, Julian A.;Elmore, Michael J.;Pollakis, Georgios;Rambaut, Andrew;Hewson, Roger;Garcia-Dorival, Isabel;Bore, Joseph Akoi;Koundouno, Raymond;Abdellati, Said;Afrough, Babak;Aiyepada, John;Akhilomen, Patience;Asogun, Danny;Atkinson, Barry;Badusche, Marlis;Bah, Amadou;Bate, Simon;Baumann, Jan;Becker, Dirk;Becker-Ziaja, Beate;Bocquin, Anne;Borremans, Benny;Bosworth, Andrew;Boettcher, Jan Peter;Cannas, Angela;Carletti, Fabrizio;Castilletti, Concetta;Clark, Simon;Colavita, Francesca;Diederich, Sandra;Donatus, Adomeh;Duraffour, Sophie;Ehichioya, Deborah;Ellerbrok, Heinz;Fernandez-Garcia, Maria Dolores;Fizet, Alexandra;Fleischmann, Erna;Gryseels, Sophie;Hermelink, Antje;Hinzmann, Julia;Hopf-Guevara, Ute;Ighodalo, Yemisi;Jameson, Lisa;Kelterbaum, Anne;Kis, Zoltan;Kloth, Stefan;Kohl, Claudia;Korva, Misa;Kraus, Annette;Kuisma, Eeva;Kurth, Andreas;Liedigk, Britta;Logue, Christopher H.;Luedtke, Anja;Maes, Piet;McCowen, James;Mely, Stephane;Mertens, Marc;Meschi, Silvia;Meyer, Benjamin;Michel, Janine;Molkenthin, Peter;Munoz-Fontela, Cesar;Muth, Doreen;Newman, Edmund N. C.;Ngabo, Didier;Oestereich, Lisa;Okosun, Jennifer;Olokor, Thomas;Omiunu, Racheal;Omomoh, Emmanuel;Pallasch, Elisa;Palyi, Bernadett;Portmann, Jasmine;Pottage, Thomas;Pratt, Catherine;Priesnitz, Simone;Quartu, Serena;Rappe, Julie;Repits, Johanna;Richter, Martin;Rudolf, Martin;Sachse, Andreas;Schmidt, Kristina Maria;Schudt, Gordian;Strecker, Thomas;Thom, Ruth;Thomas, Stephen;Tobin, Ekaete;Tolley, Howard;Trautner, Jochen;Vermoesen, Tine;Vitoriano, Ines;Wagner, Matthias;Wolff, Svenja;Yue, Constanze;Capobianchi, Maria Rosaria;Kretschmer, Birte;Hall, Yper;Kenny, John G.;Rickett, Natasha Y.;Dudas, Gytis;Coltart, Cordelia E. M.;Kerber, Romy;Steer, Damien;Wright, Callum;Senyah, Francis;Keita, Sakoba;Drury, Patrick;Diallo, Boubacar;de Clerck, Hilde;Van Herp, Michel;Sprecher, Armand;Traore, Alexis;Diakite, Mandiou;Konde, Mandy Kader;Koivogui, Lamine;Magassouba, N'Faly;Avsic-Zupanc, Tatjana;Nitsche, Andreas;Strasser, Marc;Ippolito, Giuseppe;Becker, Stephan;Stoecker, Kilian;Gabriel, Martin;Raoul, Herve;Di Caro, Antonino;Woelfel, Roman;Formenty, Pierre;Guenther, Stephan
对2014年3月至2015年1月期间在几内亚收集的179个新埃博拉病毒样本序列的分析显示了不同谱系如何在西非进化和传播。本文的在线版本（doi：10.1038/nature 14594）包含补充材料，可供授权用户使用。Miles卡罗尔及其同事的报告描述了在西非流行的埃博拉病毒的遗传进化，基于2014年3月至2015年1月期间在几内亚收集的患者样本中的179个新病毒序列。他们的分析显示了不同的血统是如何在塞拉利昂，几内亚和利比里亚之间的西非进化和传播的。本文的在线版本（doi：10.1038/nature 14594）包含补充材料，可供授权用户使用。西非目前正在目睹迄今为止有记录以来最广泛的埃博拉病毒（EBOV）爆发。到目前为止，已有27，013例报告病例和11，134例死亡。该病毒的起源被认为是2013年12月从蝙蝠到一名两岁男孩的人畜共患传播。从这一指示病例开始，病毒通过人与人之间的接触传播到几内亚、塞拉利昂和利比里亚。然而，每个国家特定病毒的来源和传播时间尚不清楚，目前依赖流行病学分析，但由于难以获得患者信息，这种分析可能不可靠。在这里，我们追踪了EBOV在当前爆发中的遗传进化，这种进化导致了多个谱系。欧洲移动的实验室是部署到几内亚疫情震中的第一个诊断单位，对179个患者样本进行深度测序，揭示了2014年3月至2015年1月疫情的流行病学和演变历史。EBOV基因组进化的分析也受益于塞拉利昂患者样本的类似测序工作。我们的结果证实，来自几内亚的埃博拉病毒很可能在4月或5月初进入塞拉利昂。几内亚/塞拉利昂谱系的病毒在2014年6月/7月左右混合。2014年8月、9月和10月的病毒序列表明，这一谱系在几内亚独立进化。这些数据可与流行病学信息结合使用，以回顾性地检验控制措施的有效性，并为了解正在发生的病毒性出血热疫情的演变提供了前所未有的窗口。本文的在线版本（doi：10.1038/nature 14594）包含补充材料，可供授权用户使用。
Analysis of 179 new Ebola virus sequences from patient samples collected in Guinea between March 2014 and January 2015 shows how different lineages evolved and spread in West Africa. The online version of this article (doi:10.1038/nature14594) contains supplementary material, which is available to authorized users. Miles Carroll and colleagues report describe the genetic evolution of Ebola virus circulating in West Africa, based on 179 new virus sequences from patient samples collected in Guinea between March 2014 and January 2015. Their analysis shows how different lineages evolved and spread in West Africa between Sierra Leone, Guinea and Liberia. The online version of this article (doi:10.1038/nature14594) contains supplementary material, which is available to authorized users. West Africa is currently witnessing the most extensive Ebola virus (EBOV) outbreak so far recorded. Until now, there have been 27,013 reported cases and 11,134 deaths. The origin of the virus is thought to have been a zoonotic transmission from a bat to a two-year-old boy in December 2013 (ref.). From this index case the virus was spread by human-to-human contact throughout Guinea, Sierra Leone and Liberia. However, the origin of the particular virus in each country and time of transmission is not known and currently relies on epidemiological analysis, which may be unreliable owing to the difficulties of obtaining patient information. Here we trace the genetic evolution of EBOV in the current outbreak that has resulted in multiple lineages. Deep sequencing of 179 patient samples processed by the European Mobile Laboratory, the first diagnostics unit to be deployed to the epicentre of the outbreak in Guinea, reveals an epidemiological and evolutionary history of the epidemic from March 2014 to January 2015. Analysis of EBOV genome evolution has also benefited from a similar sequencing effort of patient samples from Sierra Leone. Our results confirm that the EBOV from Guinea moved into Sierra Leone, most likely in April or early May. The viruses of the Guinea/Sierra Leone lineage mixed around June/July 2014. Viral sequences covering August, September and October 2014 indicate that this lineage evolved independently within Guinea. These data can be used in conjunction with epidemiological information to test retrospectively the effectiveness of control measures, and provides an unprecedented window into the evolution of an ongoing viral haemorrhagic fever outbreak. The online version of this article (doi:10.1038/nature14594) contains supplementary material, which is available to authorized users.
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影响因子：
48
作者：
Langmead, Ben;Salzberg, Steven L.
通讯作者：
Salzberg, Steven L.
影响因子：
158.5
作者：
Schieffelin, J. S.;Shaffer, J. G.;Garry, R. F.
通讯作者：
Garry, R. F.
影响因子：
4.4
作者：
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Hiscox, Julian A.
影响因子：
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作者：
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通讯作者：
Wang, Lin-Fa
DOI：
10.1126/science.1259657
发表时间：
2014-09-12
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gire SK;Goba A;Andersen KG;Sealfon RS;Park DJ;Kanneh L;Jalloh S;Momoh M;Fullah M;Dudas G;Wohl S;Moses LM;Yozwiak NL;Winnicki S;Matranga CB;Malboeuf CM;Qu J;Gladden AD;Schaffner SF;Yang X;Jiang PP;Nekoui M;Colubri A;Coomber MR;Fonnie M;Moigboi A;Gbakie M;Kamara FK;Tucker V;Konuwa E;Saffa S;Sellu J;Jalloh AA;Kovoma A;Koninga J;Mustapha I;Kargbo K;Foday M;Yillah M;Kanneh F;Robert W;Massally JL;Chapman SB;Bochicchio J;Murphy C;Nusbaum C;Young S;Birren BW;Grant DS;Scheiffelin JS;Lander ES;Happi C;Gevao SM;Gnirke A;Rambaut A;Garry RF;Khan SH;Sabeti PC
通讯作者：
Sabeti PC