Segmentectomy or Wedge Resection in Stage IA Lung Squamous Cell Carcinoma and Adenocarcinoma?
Segmentectomy or Wedge Resection in Stage IA Lung Squamous Cell Carcinoma and Adenocarcinoma?
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IA期肺鳞状细胞癌和腺癌的肺段切除术或楔形切除术？
DOI：
10.7150/jca.49683
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发表时间：
2021
影响因子：
3.9
通讯作者：
Wang C
中科院分区：
文献类型：
--
作者：
Li G;Xie S;Hu F;Tan M;Fan L;Wang C
目的：我们进行了这项研究，以比较肺段切除术（SG）和楔形切除术（WR）在IA期肺鳞状细胞癌（SQCC）和肺腺癌（AD）的生存结局。研究方法：使用监测、流行病学和最终结果登记（SEER），我们分别确定了1529例和4070例IA期SQCC和AD患者，这些患者在2004年至2015年期间具有完整的临床信息。我们使用Kaplan-Meier分析来确定基于患者术前特征的有限切除患者的倾向评分。在根据倾向评分调整、分层或匹配肺癌患者后，比较了接受WR和SG治疗的患者的肺癌特异性生存期（LCSS）。结果如下：Kaplan-Meier分析表明，SG和WR之间IA期SQCC患者的生存曲线存在统计学显着差异（log rank P=0.01）。但在IA期AD患者中，两种局限性切除术的生存曲线差异无统计学意义（log rank P>0.05）。与WR相比，SG在IA期SQCC和AD患者中的风险比（95%可信区间）分别为0.689（0.519-0.914）和0.896（0.752-1.067）。结论：本研究表明，SG可以产生上级生存结局比WR IA期SQCC患者。然而，SG和WR的生存结局在IA期AD患者中通常相当。
Objectives: We performed this study to compare survival outcomes of segmentectomy (SG) and wedge resection (WR) in stage IA lung squamous cell carcinoma (SQCC) and lung adenocarcinoma (AD). Methods: Using the Surveillance, Epidemiology, and End Results registry (SEER), we identified 1529 and 4070 patients with stage IA SQCC and AD, respectively, who had complete clinical information between 2004 and 2015. We used Kaplan-Meier analysis to determine the propensity score for patients with limited resection based on the preoperative characteristics of patients. Lung cancer-specific survival (LCSS) was compared in patients treated with WR and SG after adjusting, stratifying, or matching lung cancer patients according to propensity score. Results: Kaplan-Meier analysis demonstrated that there was a statistically significant difference in survival curves (log rank P=0.01) for patients with stage IA SQCC between SG and WR. But there was no statistically significant difference in survival curves (log rank P>0.05) in patients with stage IA AD between the two limited resections. Compared with the WR, The hazard ratios (95% confidence intervals) of SG were 0.689 (0.519-0.914) and 0.896 (0.752-1.067) in patients with stage IA SQCC and AD, respectively. Conclusion: This study suggests that SG can yield superior survival outcome compared with WR in patients with stage IA SQCC. However, the survival outcomes of SG and WR are generally equivalent in patients with stage IA AD.
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影响因子：
4.3
作者：
Hou B;Deng XF;Zhou D;Liu QX;Dai JG
通讯作者：
Dai JG
影响因子：
3.4
作者：
Sugi, Kazuro;Kobayashi, Seiki;Okabe, Kazunori
通讯作者：
Okabe, Kazunori
影响因子：
6
作者：
Koike, T;Yamato, Y;Suzuki, R
通讯作者：
Suzuki, R
影响因子：
2.5
作者：
Harrison, Sebron;Stiles, Brendon;Altorki, Nasser
通讯作者：
Altorki, Nasser
DOI：
10.1016/j.jtcvs.2013.09.065
发表时间：
2014-02-01
影响因子：
6
作者：
Altorki, Nasser K.;Yip, Rowena;Henschke, Claudia I.
通讯作者：
Henschke, Claudia I.