Controllable Acoustic Mixing of Fluids in Microchannels for the Fabrication of Therapeutic Nanoparticles.
Controllable Acoustic Mixing of Fluids in Microchannels for the Fabrication of Therapeutic Nanoparticles.
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DOI：
10.3390/mi7090150
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发表时间：
2016-09-02
期刊：
影响因子：
3.4
通讯作者：
Wixforth A
中科院分区：
文献类型：
--
作者：
Westerhausen C;Schnitzler LG;Wendel D;Krzysztoń R;Lächelt U;Wagner E;Rädler JO;Wixforth A
十五年前，人们发现声表面波 (SAW) 能够驱动流体，此后微流体领域的众多应用得到了开发。在这里，我们回顾了所取得的进展并报告了建立微流体、连续流声学混合的新方法。在微通道中，通过产生垂直于平均流动方向的 SAW 驱动流体射流来实现混沌平流。我们使用高速摄像机和粒子图像测速仪测量流速，并表明混合是以特别可控且快速的方式实现的。混合质量取决于系统参数：SAW 功率、体积通量和流体粘度。探索混合的参数空间为微通道中的声学混合提供了实用指南，并允许采用不同溶剂的条件，例如从醇相生成纳米级颗粒所需的条件。我们示例性地展示了基于 SAW 的连续流动混合用于生产由聚合物和脂质溶液组装的治疗性核酸纳米颗粒的潜力。
Fifteen years ago, surface acoustic waves (SAW) were found to be able to drive fluids and numerous applications in microfluidics have been developed since. Here, we review the progress made and report on new approaches in setting-up microfluidic, continuous flow acoustic mixing. In a microchannel, chaotic advection is achieved by generation of a SAW driven fluid jet perpendicular to the mean flow direction. Using a high speed video camera and particle image velocimetry, we measure the flow velocities and show that mixing is achieved in a particularly controllable and fast way. The mixing quality is determined as a function of system parameters: SAW power, volume flux and fluid viscosity. Exploring the parameter space of mixing provides a practical guide for acoustic mixing in microchannels and allows for adopting conditions to different solvents, as e.g., required for the generation of nanoscale particles from alcoholic phases. We exemplarily demonstrate the potential of SAW based continuous flow mixing for the production of therapeutic nucleic acid nanoparticles assembled from polymer and lipid solutions.
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影响因子：
44.1
作者：
Friend, James;Yeo, Leslie Y.
通讯作者：
Yeo, Leslie Y.
影响因子：
4.2
作者：
Cheng, Nian-Sheng
通讯作者：
Cheng, Nian-Sheng
DOI：
10.1073/pnas.0608422104
发表时间：
2007-05-08
影响因子：
11.1
作者：
Schneider, S. W.;Nuschele, S.;Schneider, M. F.
通讯作者：
Schneider, M. F.
影响因子：
5.8
作者：
PONS, M;FORADADA, M;ESTELRICH, J
通讯作者：
ESTELRICH, J
影响因子：
6.1
作者：
Guttenberg, Z;Müller, H;Wixforth, A
通讯作者：
Wixforth, A