A catalogue of Triticum monococcum genes encoding toxic and immunogenic peptides for celiac disease patients.
A catalogue of Triticum monococcum genes encoding toxic and immunogenic peptides for celiac disease patients.
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DOI：
10.1007/s00438-008-0412-8
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发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Kilian B
中科院分区：
文献类型：
--
作者：
Vaccino P;Becker HA;Brandolini A;Salamini F;Kilian B
乳糜泻（CD）是一种炎症性疾病，其特征是在暴露于小麦、大麦和黑麦的麸质时对小肠衬里的损伤。人们在面包小麦中详细研究了麸质与CD综合征的关系，并定义了一组“有毒”和“免疫原性”肽。对于小麦二倍体物种，CD表位的信息是穷人。在本文中，我们采用了基因组的方法，以了解潜在的CD危险代表的二倍体小麦和测序足够多的cDNA克隆相关的贮藏蛋白基因的一粒小麦的贮藏蛋白基因。结果表明，在所有的贮藏蛋白中均含有有害序列，其中有4种为真正的毒性肽，13种为免疫原性肽。主要结论是，一粒小麦具有诱导CD综合征的全部潜力，这在多倍体小麦中已经很明显。此外，本文还对T.本发明提供了一种包含一个全长HMW x型序列和两个部分HMW y型序列的单球菌的DNA序列。本文的在线版本（doi：10.1007/s 00438 -008-0412-8）包含补充材料，可供授权用户使用。
The celiac disease (CD) is an inflammatory condition characterized by injury to the lining of the small-intestine on exposure to the gluten of wheat, barley and rye. The involvement of gluten in the CD syndrome has been studied in detail in bread wheat, where a set of “toxic” and “immunogenic” peptides has been defined. For wheat diploid species, information on CD epitopes is poor. In the present paper, we have adopted a genomic approach in order to understand the potential CD danger represented by storage proteins in diploid wheat and sequenced a sufficiently large number of cDNA clones related to storage protein genes of Triticum monococcum. Four bona fide toxic peptides and 13 immunogenic peptides were found. All the classes of storage proteins were shown to contain harmful sequences. The major conclusion is that einkorn has the full potential to induce the CD syndrome, as already evident for polyploid wheats. In addition, a complete overview of the storage protein gene arsenal in T. monococcum is provided, including a full-length HMW x-type sequence and two partial HMW y-type sequences. The online version of this article (doi:10.1007/s00438-008-0412-8) contains supplementary material, which is available to authorized users.
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影响因子：
4.4
作者：
Gianfrani, C;Troncone, R;Sette, A
通讯作者：
Sette, A
影响因子：
15.3
作者：
Arentz-Hansen, H;Korner, R;Molberg, O;Quarsten, H;Vader, W;Kooy, Y M;Lundin, K E;Koning, F;Roepstorff, P;Sollid, L M;McAdam, S N
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影响因子：
10.7
作者：
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Salamini, F.
影响因子：
5.4
作者：
Arbelbide, M;Bernardo, R
通讯作者：
Bernardo, R
DOI：
10.1073/pnas.072223799
发表时间：
2002-06-11
影响因子：
11.1
作者：
Huang, S;Sirikhachornkit, A;Gornicki, P
通讯作者：
Gornicki, P