Epidermal stem cell diversity and quiescence.
Epidermal stem cell diversity and quiescence.
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DOI：
10.1002/emmm.200900033
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发表时间：
2009-08
影响因子：
11.1
通讯作者：
Jensen, Kim B.
中科院分区：
文献类型：
--
作者：
Watt, Fiona M.;Jensen, Kim B.
哺乳动物表皮是通过干细胞的自我更新和其后代的终末分化来维持的。新的数据揭示了干细胞之间的多样性，这是以前没有认识到的。不同的干细胞群具有不同的位置，并且在它们是静止的还是活跃的循环方面有所不同。在正常的表皮稳态期间，每个干细胞群体供养有限数量的分化谱系。然而，为了响应损伤或遗传操作，不同的干细胞库表现出多谱系分化能力。虽然已经确定Wnt信号促进毛囊（HF）分化，但新的观察结果表明EGF受体信号在促进毛囊间表皮分化中的作用。NFATc1在HF中维持静止，而Lrig1在交界区发挥相同的功能。现在的阶段是探索不同的表皮干细胞群之间的关系和之间的静止和谱系选择。
Mammalian epidermis is maintained by self-renewal of stem cells and terminal differentiation of their progeny. New data reveal a diversity amongst stem cells that was previously unrecognized. Different stem cell populations have different locations and differ in whether they are quiescent or actively cycling. During normal epidermal homeostasis, each stem cell population feeds a restricted number of differentiated lineages. However, in response to injury or genetic manipulation the different pools of stem cells demonstrate multi-lineage differentiation ability. While it is well established that Wnt signalling promotes hair follicle (HF) differentiation, new observations suggest a role for EGF receptor signalling in promoting differentiation of interfollicular epidermis. NFATc1 maintains quiescence in the HF, while Lrig1 exerts the same function in the junctional zone. The stage is now set for exploring the relationship between the different epidermal stem cell populations and between quiescence and lineage selection.
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