Mesenchymal Stem Cell Transplantation: Neuroprotection and Nerve Regeneration After Spinal Cord Injury.
Mesenchymal Stem Cell Transplantation: Neuroprotection and Nerve Regeneration After Spinal Cord Injury.
复制标题
DOI：
10.2147/jir.s428425
复制
发表时间：
2023
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
--
作者：
脊髓损伤（Spinal Cord Injury， SCI）是一种对患者生理和心理都具有高度破坏性的疾病，具有高致残率和高死亡率的发病率特点，目前还缺乏有效的治疗方法。脊髓损伤后，一系列继发性损伤反应如缺血、外周炎症细胞浸润、氧化应激等，形成了一个不利于神经恢复的微环境，最终导致神经元和胶质细胞凋亡和坏死。间充质干细胞（MSC）移植近年来成为一种更有前途的治疗选择。MSC可通过免疫调节、神经保护、神经再生等多种机制促进脊髓损伤修复，给脊髓损伤患者带来希望。本文讨论了间充质干细胞治疗脊髓损伤的神经保护和神经再生成分。
Spinal Cord Injury (SCI), with its morbidity characteristics of high disability rate and high mortality rate, is a disease that is highly destructive to both the physiology and psychology of the patient, and for which there is still a lack of effective treatment. Following spinal cord injury, a cascade of secondary injury reactions known as ischemia, peripheral inflammatory cell infiltration, oxidative stress, etc. create a microenvironment that is unfavorable to neural recovery and ultimately results in apoptosis and necrosis of neurons and glial cells. Mesenchymal stem cell (MSC) transplantation has emerged as a more promising therapeutic options in recent years. MSC can promote spinal cord injury repair through a variety of mechanisms, including immunomodulation, neuroprotection, and nerve regeneration, giving patients with spinal cord injury hope. In this paper, it is discussed the neuroprotection and nerve regeneration components of MSCs’ therapeutic method for treating spinal cord injuries.
影响因子：
1.7
作者：
Moayeri, Ardeshir;Alizadeh, Rafieh;Hamidabadi, Hatef Ghasemi;Bojnordi, Maryam Nazm;Niapour, Ali;Hedayatpour, Azim;Darvishi, Marzieh;Heidari, Fatemeh;Soleimani, Maryam;Elyasi, Leila
通讯作者：
Elyasi, Leila