Clinical Characteristics of Methanol-Induced Optic Neuropathy: Correlation between Aetiology and Clinical Findings.
Clinical Characteristics of Methanol-Induced Optic Neuropathy: Correlation between Aetiology and Clinical Findings.
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甲醇引起的视神经病变的临床特征：病因与临床表现之间的相关性
DOI：
10.1155/2022/4671671
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发表时间：
2022
影响因子：
1.9
通讯作者：
Zhou, Huanfen
中科院分区：
文献类型：
--
作者：
Sun, Qiao;Sun, Mingming;Zhang, Yuan;Wang, Song;Bai, Wenhao;Wei, Shihui;Xu, Quangang;Zhou, Huanfen
为显示其临床特点，明确其磁共振成像(MRI)和光学相干断层扫描(OCT)特征，并观察甲醇所致视神经病变的视觉转归。临床资料回顾性收集自2016年1月至2021年1月在中国人解放军总医院神经眼科住院确诊的甲醇所致视神经病变患者。这项研究包括8名患者。暴露时间：摄入6~34 h，吸入3~4个月，皮肤吸收10年以上。所有患者均表现为双眼急性视力损害。8名患者中有7名有其他伴随的全身症状。8例患者中有7例在MRI上发现视神经病变，5例表现为“中央型”的高T2信号。OCT显示黄斑神经节细胞层和内丛状层(MgCl-IPL)变薄，乳头周围视网膜神经纤维层(PRNFL)变薄。8名患者中有7名在治疗后视力一过性改善。一名线粒体DNA突变的患者从发病到最后一次就诊一直保持着双侧无光知觉(NLP)。所有患者的视力预后都很差，要么有光感，要么有NLP。甲醇诱导的视神经病变是一种罕见的双侧视神经病变，视力预后较差。视神经中心高信号T2信号在甲醇诱导的视神经病变中很常见。在早期诊断中，氯化镁-IPL变薄比pRNFL更敏感。线粒体遗传缺陷可能是甲醇所致视神经病变的易感因素。
To show the clinical characteristics, identify the magnetic resonance imaging (MRI) and optical coherence tomography (OCT) features, and observe the visual outcome of methanol-induced optic neuropathy. Clinical data were retrospectively collected from in-patients diagnosed with methanol-induced optic neuropathy in the Neuro-Ophthalmology Department of the Chinese People's Liberation Army General Hospital from January 2016 to January 2021. Eight patients were included in this study. The exposure time was 6–34 h for ingestion, 3-4 months for inhalation, and more than ten years for skin absorption. All patients demonstrated bilateral acute visual impairment. Seven of eight patients had other accompanying systemic symptoms. Seven of eight patients demonstrated optic nerve lesions in MRI, and five presented with a hyperintense T2 signal in a “central” type. OCT showed the macular ganglion cell layer and inner plexiform layer (mGCL-IPL) thinning before the peripapillary retinal nerve fiber layer (pRNFL) thinning. The visual improvement was achieved transiently for seven of eight patients after treatment. One patient with a mitochondrial DNA mutation maintained a bilateral no-light perception (NLP) from the onset to the last visit. All patients had poor visual prognoses, with either light perception or NLP. Methanol-induced optic neuropathy is a rare bilateral optic neuropathy with a poor visual outcome. A centrally hyperintense T2 signal of the optic nerve is common in methanol-induced optic neuropathy. The thinning of the mGCL-IPL is more sensitive than that of the pRNFL for early diagnosis. A mitochondrial genetic defect may be a predisposing factor for methanol-induced optic neuropathy.
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DOI：
10.3390/ijerph19053092
发表时间：
2022-03-06
影响因子：
--
作者：
Baj J;Forma A;Kobak J;Tyczyńska M;Dudek I;Maani A;Teresiński G;Buszewicz G;Januszewski J;Flieger J
通讯作者：
Flieger J
影响因子：
2.9
作者：
Blanc, Christelle;Heran, Francoise;Vignal-Clermont, Catherine
通讯作者：
Vignal-Clermont, Catherine
影响因子：
0.4
作者：
Dogan H;Yilmaz Karakus B;Serefoglu Cabuk K;Uzun O;Yenice H;Orucoglu A
通讯作者：
Orucoglu A
影响因子：
2.9
作者：
Chua, Jacqueline;Tan, Bingyao;Schmetterer, Leopold
通讯作者：
Schmetterer, Leopold
影响因子：
--
作者：
Lucaciu, Alexandra;Samp, Patrick Felix;Hattingen, Elke;Kestner, Roxane-Isabelle;Davidova, Petra;Kohnen, Thomas;Rudolph, Jasmin;Dietz, Andreas;Steinmetz, Helmuth;Strzelczyk, Adam
通讯作者：
Strzelczyk, Adam