Nanotechnology-Based Strategies to Overcome Current Barriers in Gene Delivery.
Nanotechnology-Based Strategies to Overcome Current Barriers in Gene Delivery.
复制标题
以纳米技术为基础的克服目前基因传递障碍的策略。
DOI：
10.3390/ijms22168537
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发表时间：
2021-08-09
影响因子：
5.6
通讯作者：
Trigueros S
中科院分区：
文献类型：
--
作者：
Mirón-Barroso S;Domènech EB;Trigueros S
目前正在开发用于特定细胞/组织/器官传递遗传物质的纳米材料。纳米材料被认为是用于基因治疗的非病毒载体。然而，要开发一种足够小的设备来成为有效的基因传递工具，有几个要求。考虑到到目前为止测试的非病毒载体的基因传递效率非常低，有必要开发基于纳米技术的策略来克服目前基因传递中的障碍。选定的纳米结构可以结合几种遗传物质，如质粒DNA、信使核糖核酸和小干扰RNA。在纳米技术领域，其作为基因递送系统的应用仍有一些局限性有待解决，如潜在的毒性和低的转染率。不可否认，纳米级的新特性对于克服这些限制是必不可少的。在本文中，我们将探讨纳米技术在基因传递领域的最新进展。
Nanomaterials are currently being developed for the specific cell/tissue/organ delivery of genetic material. Nanomaterials are considered as non-viral vectors for gene therapy use. However, there are several requirements for developing a device small enough to become an efficient gene-delivery tool. Considering that the non-viral vectors tested so far show very low efficiency of gene delivery, there is a need to develop nanotechnology-based strategies to overcome current barriers in gene delivery. Selected nanostructures can incorporate several genetic materials, such as plasmid DNA, mRNA, and siRNA. In the field of nanotechnologies, there are still some limitations yet to be resolved for their use as gene delivery systems, such as potential toxicity and low transfection efficiency. Undeniably, novel properties at the nanoscale are essential to overcome these limitations. In this paper, we will explore the latest advances in nanotechnology in the gene delivery field.
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