Global Circumferential Strain by Cardiac Magnetic Resonance Tissue Tracking Associated With Ventricular Arrhythmias in Hypertrophic Cardiomyopathy Patients.
Global Circumferential Strain by Cardiac Magnetic Resonance Tissue Tracking Associated With Ventricular Arrhythmias in Hypertrophic Cardiomyopathy Patients.
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心脏磁共振组织追踪的全球周向应变与肥厚型心肌病患者的室性心律失常相关
DOI：
10.3389/fcvm.2021.670361
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发表时间：
2021
影响因子：
3.6
通讯作者：
Hu H
中科院分区：
文献类型：
--
作者：
Pu C;Fei J;Lv S;Wu Y;He C;Guo D;Mabombo PU;Chooah O;Hu H
背景：肥厚性心肌病（HCM）容易发生心肌异质性和纤维化，这是室性心律失常（VAs）的基础。心脏磁共振组织跟踪（CMR-TT）可以从不同方向定量反映整体和局部左室应变。CMR-TT检测到的心肌应变变化是否与VAs相关尚不确定。本研究旨在探讨CMR-TT对HCM的VAs鉴别诊断价值。材料和方法：我们回顾性地纳入了93例HCM患者（38例有VAs， 55例无VAs）和30例健康患者。观察左心室功能、心肌应变参数及晚期钆增强百分率（%LGE）。结果：GCS与%LGE有中等相关性（r = 0.51, P < 0.001）。有VAs的HCM患者左室射血分数（LVEF）、总径向应变（GRS）、GCS和总纵向应变（GLS）均较低，但LGE %较无VAs组升高（P < 0.01）。通过多因素logistic回归分析，LGE和GCS作为HCM患者VAs的指标。CMR评分为%LGE >- 5.35% （AUC 0.81, 95% CI 0.70-0.91, P < 0.001）或GCS >-14.73% （AUC 0.79, 95% CI 0.70-0.89, P < 0.001）的HCM患者出现VAs的频率更高。%LGE + GCS能够更好地识别HCM患者的VAs （AUC 0.87, 95% CI 0.79 ~ 0.95, P < 0.001）。结论：GCS和%LGE是HCM患者VAs的独立危险指标。GCS有望成为识别HCM患者VAs的良好潜在预测指标，为临床实践中改善HCM的风险分层提供重要价值。
Background: Hypertrophic cardiomyopathy (HCM) is prone to myocardial heterogeneity and fibrosis, which are the substrates of ventricular arrhythmias (VAs). Cardiac magnetic resonance tissue tracking (CMR-TT) can quantitatively reflect global and regional left ventricular strain from different directions. It is uncertain whether the change of myocardial strain detected by CMR-TT is associated with VAs. The aim of the study is to explore the differential diagnostic value of VAs in HCM by CMR-TT. Materials and Methods: We retrospectively included 93 HCM patients (38 with VAs and 55 without VAs) and 30 healthy cases. Left ventricular function, myocardial strain parameters and percentage of late gadolinium enhancement (%LGE) were evaluated. Results: Global circumferential strain (GCS) and %LGE correlated moderately (r = 0.51, P < 0.001). HCM patients with VAs had lower left ventricular ejection fraction (LVEF), global radial strain (GRS), GCS, and global longitudinal strain (GLS), but increased %LGE compared with those without VAs (P < 0.01 for all). %LGE and GCS were indicators of VAs in HCM patients by multivariate logistic regression analysis. HCM patients with %LGE >5.35% (AUC 0.81, 95% CI 0.70–0.91, P < 0.001) or GCS >-14.73% (AUC 0.79, 95% CI 0.70–0.89, P < 0.001) on CMR more frequently had VAs. %LGE + GCS were able to better identify HCM patients with VAs (AUC 0.87, 95% CI 0.79–0.95, P < 0.001). Conclusion: GCS and %LGE were independent risk indicators of VAs in HCM. GCS is expected to be a good potential predictor in identifying HCM patients with VAs, which may provide important values to improve risk stratification in HCM in clinical practice.
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DOI：
10.1111/j.1540-8175.2011.01427.x
发表时间：
2011-08-01
影响因子：
1.5
作者：
Correia, Emanuel;Rodrigues, Bruno;Santos, Oliveira
通讯作者：
Santos, Oliveira
影响因子：
39.3
作者：
Elliott, Perry M.;Anastasakis, Aris;Watkins, Hugh
通讯作者：
Watkins, Hugh
影响因子：
5.5
作者：
Baxi, Ameya Jagdish;Restrepo, Carlos S.;Murillo, Horacio
通讯作者：
Murillo, Horacio
影响因子：
39.3
作者：
Papavassiliu, T;Schnabel, P;Borggrefe, M
通讯作者：
Borggrefe, M
影响因子：
39.3
作者：
Elliott, Perry;Andersson, Bert;Keren, Andre
通讯作者：
Keren, Andre