Prognostic significance of maximum primary tumor diameter in nasopharyngeal carcinoma.
Prognostic significance of maximum primary tumor diameter in nasopharyngeal carcinoma.
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DOI：
10.1186/1471-2407-13-260
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发表时间：
2013-05-27
期刊：
影响因子：
3.8
通讯作者：
Chen Y
中科院分区：
文献类型：
--
作者：
Liang SB;Deng YM;Zhang N;Lu RL;Zhao H;Chen HY;Li SE;Liu DS;Chen Y
目的：评价鼻咽癌最大原发肿瘤直径(MPTD)对预后的影响。对连续333例新诊断的鼻咽癌患者进行了回顾性研究。采用Kaplan-Meier分析和LOG-RANK检验估计总生存率(OS)、无失败生存率(FFS)、无远处转移生存率(DMFS)和无局部复发生存率(LRFS)。COX比例风险回归分析评价MPTD的预后价值。中位随访时间为66个月(2-82个月)。T1、T2、T3、T4期MPTD中位数分别为27.9、37.5、45.0、61.3 mm。 ≤ 为30 mm的T1患者占62.3%，T2和T3患者分别有72%和62.9%的患者 &> 为30~50 mm，83.5%的T4患者 &> 为50 mm。 ≤ 为30 mm、30~50 mm和 >； 为50 mm的患者，5年OS、FFS、DMFS和LRFS率分别为85.2%、74.2%和56.3%(P <； 0.001)；87%、80.7%和62.8%(P <； 0.001)；88.7%、86.4%和72.5%(P = 0.003)；分别为98.2%、93.2%和86.3%(P = 0.012)。在多因素分析中，MPTD是OS、FFS和DMFS的预后因素，也是LRFS的唯一独立预后因素。对于 ≤ 为50 mm和 >； 为50 mm的T3-T4患者，5年OS、FFS和DMFS率分别为70.4%和58.4%(P = 0.010)、77.5%和65.2%(P = 0.013)和83.6%和73.6%(P = 0.047)。 ≤ 为30 mm的患者，T1、T2、T3和T4的5年生存率分别为100%、100%、88.9%和100%(P = 0.172)。我们的数据表明，MPTD是鼻咽癌的一个独立预后因素，合并MPTD可能导致T分期的进一步完善。
To evaluate the prognostic value of maximum primary tumor diameter (MPTD) in nasopharyngeal carcinoma (NPC). Three hundred and thirty-three consecutive, newly-diagnosed NPC patients were retrospectively reviewed. Kaplan-Meier analysis and the log-rank test were used to estimate overall survival (OS), failure-free survival (FFS), distant metastasis-free survival (DMFS) and local relapse-free survival (LRFS). Cox proportional hazards regression analysis was used to assess the prognostic value of MPTD. Median follow-up was 66 months (range, 2–82 months). Median MPTD in stage T1, T2, T3 and T4 was 27.9, 37.5, 45.0 and 61.3 mm, respectively. The proportion of T1 patients with a MPTD ≤ 30 mm was 62.3%; 72% and 62.9% of T2 and T3 patients had a MPTD > 30–50 mm, and 83.5% of T4 patients had a MPTD > 50 mm. For patients with a MPTD ≤ 30 mm, > 30–50 mm and > 50 mm, the 5-year OS, FFS, DMFS and LRFS rates were 85.2%, 74.2% and 56.3% (P < 0.001); 87%, 80.7% and 62.8% (P < 0.001); 88.7%, 86.4% and 72.5% (P = 0.003); and 98.2%, 93.2% and 86.3% (P = 0.012), respectively. In multivariate analysis, MPTD was a prognostic factor for OS, FFS and DMFS, and the only independent prognostic factor for LRFS. For T3-T4 patients with a MPTD ≤ 50 mm and > 50 mm, the 5-year OS, FFS and DMFS rates were 70.4% vs. 58.4% (P = 0.010), 77.5% vs. 65.2% (P = 0.013) and 83.6% vs. 73.6% (P = 0.047), respectively. In patients with a MPTD ≤ 30 mm, 5-year LRFS in T1, T2, T3 and T4 was 100%, 100%, 88.9% and 100% (P = 0.172). Our data suggest that MPTD is an independent prognostic factor in NPC, and incorporation of MPTD might lead to a further refinement of T staging.
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影响因子：
3.8
作者：
Ferrari D;Codecà C;Bertuzzi C;Broggio F;Crepaldi F;Luciani A;Floriani I;Ansarin M;Chiesa F;Alterio D;Foa P
通讯作者：
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发表时间：
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影响因子：
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影响因子：
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作者：
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通讯作者：
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10.1016/j.ijrobp.2008.03.017
发表时间：
2008-12-01
影响因子：
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