Role of plasma EBV DNA levels in predicting recurrence of nasopharyngeal carcinoma in a Western population.
Role of plasma EBV DNA levels in predicting recurrence of nasopharyngeal carcinoma in a Western population.
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DOI：
10.1186/1471-2407-12-208
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发表时间：
2012-05-30
期刊：
影响因子：
3.8
通讯作者：
Foa P
中科院分区：
文献类型：
--
作者：
Ferrari D;Codecà C;Bertuzzi C;Broggio F;Crepaldi F;Luciani A;Floriani I;Ansarin M;Chiesa F;Alterio D;Foa P
局部晚期鼻咽癌可以通过化疗和放疗的联合治疗而治愈。在东方国家，血浆EB病毒脱氧核糖核酸（DNA）水平在预测复发方面是准确的，但在西方人群中几乎没有数据。这项前瞻性研究的目的是评估血浆中病毒Epstein-Barr DNA拷贝数与西方IIb-IVb期鼻咽癌患者队列的缓解率、无进展生存期和总生存期之间的关系。我们评估了36例连续接受诱导化疗和放化疗的患者的血浆样本。DNA提取后采用实时定量聚合酶链反应测定EBV拷贝数。使用Kaplan-Meier方法估计存活曲线。在治疗前、伴随化疗和放疗结束时以及随访期间测量循环EB病毒DNA水平。治疗前水平与初始阶段和复发概率显著相关。在检测局部或转移性复发方面，其特异性为100%，敏感性为71.3%（总体准确性为94.4%）。3年无进展生存率和总生存率分别为78.2%和97.1%。这项研究的结果证实，来自西方国家的局部晚期鼻咽癌患者在诊断时血浆EB病毒DNA水平较高。血浆水平的监测在检测疾病复发和转移方面是敏感和高度特异的。
Loco-regionally advanced nasopharyngeal carcinomas can be cured by the combination of chemotherapy and radiotherapy. In Eastern countries, plasma levels of viral Epstein-Barr deoxyribonucleic acid (DNA) are accurate in predicting recurrence, but few data are available in Western populations. The aim of this prospective study was to evaluate the relationship between viral Epstein-Barr DNA copy numbers in plasma and the response rate, progression-free survival and overall survival in a cohort of Western patients with stage IIb-IVb nasopharyngeal cancer. We evaluated plasma samples from 36 consecutive patients treated with induction chemotherapy followed by chemoradiation. EBV copy numbers were determined after DNA extraction using real-time quantitative polymerase chain reaction. Survival curves were estimated using the Kaplan–Meier method. Circulating Epstein-Barr virus DNA levels were measured before treatment, at the end of concomitant chemo- and radiotherapy, and during the follow-up period. Pre-treatment levels significantly correlated with the initial stage and probability of relapse. Their increase was 100% specific and 71.3% sensitive in detecting loco-regional or metastatic recurrence (an overall accuracy of 94.4%). Three-year progression-free and overall survival were respectively 78.2% and 97.1%. The results of this study confirm that patients from a Western country affected by loco-regionally advanced nasopharyngeal carcinoma have high plasma Epstein-Barr virus DNA levels at diagnosis. The monitoring of plasma levels is sensitive and highly specific in detecting disease recurrence and metastases.
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DOI：
10.1002/hed.20833
发表时间：
2008-07
影响因子：
2.9
作者：
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