Normalization of network connectivity in hemispatial neglect recovery.
Normalization of network connectivity in hemispatial neglect recovery.
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DOI：
10.1002/ana.24690
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发表时间：
2016-07
影响因子：
11.2
通讯作者：
Corbetta M
中科院分区：
文献类型：
--
作者：
Ramsey LE;Siegel JS;Baldassarre A;Metcalf NV;Zinn K;Shulman GL;Corbetta M
我们最近报道了脑卒中半空间忽视患者的空间和非空间注意缺陷在发病2周后与多脑网络静息状态功能磁共振成像（R-fMRI）测量的半球间和半球内功能连通性（FC）的广泛改变相关。忽视恢复的机制在很大程度上是未知的。在这项研究中，我们检验了一个假设，即半空间忽视的恢复与网络连接向正常模式的回归相关，这里定义为“网络正常化”。我们在发病后平均2周（n=99）、3个月（n=77）和12个月（n=64）时，用神经心理学电池测量了大量中风患者的注意缺陷和FC。行为改善和FC变化之间的关系通过已知亚急性异常的先验区域和网络以及数据驱动的方式进行了分析。注意缺陷恢复大多在3个月前完成，并且与许多网络中异常FC的正常化显著相关。注意缺陷的改善，独立于最初的严重程度，与先前在注意、感觉和运动网络中抑郁的半球间FC的改善，以及背侧注意/运动区域和默认模式/额顶叶区域之间正常反相关性的恢复相关，特别是在受损半球。这些结果表明，半空间忽视的异常网络连接与行为相关。因此，回归正常的网络相互作用，以及可能的最佳信息处理，是一种系统级机制，与局灶性损伤后注意力的改善有关。
We recently reported that spatial and non-spatial attention deficits in stroke patients with hemi-spatial neglect are correlated at 2 weeks post-onset with widespread alterations of inter-hemispheric and intra-hemispheric functional connectivity (FC) measured with resting state fMRI (R-fMRI) across multiple brain networks. The mechanisms underlying neglect recovery are largely unknown. In this study we test the hypothesis that recovery of hemi-spatial neglect correlates with a return of network connectivity toward a normal pattern, herein defined as ‘network normalization’. We measured attention deficits with a neuropsychological battery, and FC in a large cohort of stroke patients at, on average, 2 weeks (n=99), 3 months (n=77), and 12 (n=64) months post onset. The relationship between behavioral improvement and changes in FC was analyzed both in terms of a priori regions and networks known to be abnormal sub-acutely, and in a data driven manner. Attention deficit recovery was mostly complete by 3 months, and was significantly correlated with a normalization of abnormal FC across many networks. Improvement of attention deficits, independent of initial severity, was correlated with improvements of previously depressed inter-hemispheric FC across attention, sensory, and motor networks, and a restoration of the normal anti-correlation between dorsal attention/motor regions and default-mode/frontoparietal regions, particularly in the damaged hemisphere. These results demonstrate that abnormal network connectivity in hemi-spatial neglect is behaviorally relevant. A return toward normal network interactions, and presumably optimal information processing, is therefore a systems level mechanism that is associated with improvements of attention over time after focal injury.
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影响因子：
5.7
作者：
Grefkes C;Nowak DA;Wang LE;Dafotakis M;Eickhoff SB;Fink GR
通讯作者：
Fink GR
影响因子：
16.2
作者：
Corbetta M;Ramsey L;Callejas A;Baldassarre A;Hacker CD;Siegel JS;Astafiev SV;Rengachary J;Zinn K;Lang CE;Connor LT;Fucetola R;Strube M;Carter AR;Shulman GL
通讯作者：
Shulman GL
影响因子：
5.3
作者：
Bonnelle, Valerie;Leech, Robert;Sharp, David J.
通讯作者：
Sharp, David J.
影响因子：
5.7
作者：
Castellanos, Nazareth P.;Leyva, Inmaculada;del-Pozo, Francisco
通讯作者：
del-Pozo, Francisco
影响因子：
14.5
作者：
Baldassarre, Antonello;Ramsey, Lenny;Corbetta, Maurizio
通讯作者：
Corbetta, Maurizio