Engineering biological systems with synthetic RNA molecules.
Engineering biological systems with synthetic RNA molecules.
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DOI:
10.1016/j.molcel.2011.08.023
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发表时间:
2011-09-16
期刊:
影响因子:
16
通讯作者:
Smolke CD
中科院分区:
文献类型:
--
作者:
Liang JC;Bloom RJ;Smolke CD
RNA molecules play diverse functional roles in natural biological systems. There has been growing interest in designing synthetic RNA counterparts for programming biological function. The design of synthetic RNA molecules that exhibit diverse activities, including sensing, regulatory, information processing, and scaffolding activities, has highlighted the advantages of RNA as a programmable design substrate. Recent advances in implementing these engineered RNA molecules as key control elements in synthetic genetic networks are highlighting the functional relevance of this class of synthetic elements in programming cellular behaviors.
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