Engineering biological systems with synthetic RNA molecules.

Engineering biological systems with synthetic RNA molecules.
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DOI:
10.1016/j.molcel.2011.08.023
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发表时间:
2011-09-16
期刊:
影响因子:
16
通讯作者:
Smolke CD
Smolke CD
中科院分区:
生物学1区
文献类型:
--
作者:
Liang JC;Bloom RJ;Smolke CD

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RNA分子在自然生物系统中发挥着多种功能作用。人们对设计用于编程生物功能的合成RNA对应物越来越感兴趣。合成RNA分子的设计表现出不同的活动,包括传感,调节,信息处理和支架活动,突出了RNA作为可编程设计底物的优势。在实施这些工程RNA分子作为合成遗传网络中的关键控制元件的最新进展突出了这类合成元件在编程细胞行为中的功能相关性。
RNA molecules play diverse functional roles in natural biological systems. There has been growing interest in designing synthetic RNA counterparts for programming biological function. The design of synthetic RNA molecules that exhibit diverse activities, including sensing, regulatory, information processing, and scaffolding activities, has highlighted the advantages of RNA as a programmable design substrate. Recent advances in implementing these engineered RNA molecules as key control elements in synthetic genetic networks are highlighting the functional relevance of this class of synthetic elements in programming cellular behaviors.
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