Alcohol and heart muscle disease
Alcohol and heart muscle disease
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酒精与心肌疾病
DOI：
10.1080/13556219772822
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发表时间：
1997
影响因子：
3.4
通讯作者：
A. Urbano
中科院分区：
文献类型：
--
作者：
J. Fernandez;R. Estruch;A. Urbano
摘要乙醇可引起急性和慢性心肌损伤。高剂量急性乙醇摄入可诱导心肌收缩减少并产生各种节律紊乱。这些影响在基础心肌病患者中更相关。慢性乙醇摄入可能诱发扩张型心肌病的发生，其在临床和功能上与特发性扩张型心肌病相似。酒精性心肌病在戒酒后可能是可逆的。预后取决于酒精摄入的持续或节制。酒精性心肌病与其他乙醇相关疾病（如骨骼肌病和肝硬化）之间存在正相关性。在患有特定乙醇相关疾病的患者中，应排除其他酒精中毒并发症的可能存在。虽然有几个因素可能与酒精相关心肌损伤的发病机制有关，但乙醇本身可能诱导直接心肌损伤，这与剂量相关，与营养、蛋白质或离子缺乏无关。酒精性心肌病最相关的致病性研究是基于乙醇介导的膜通透性和离子通量的破坏，诱导通过肌膜的钙瞬变减少并干扰肌细胞的兴奋-收缩偶联。细胞能量消耗或蛋白质周转中断可能导致乙醇对心肌的有害影响。
Abstract Ethanol consumption may induce acute and chronic effects on the myocardium. High‐dose acute ethanol intake may induce a decrease in myocardial contraction and produce a variety of rhythm disturbances. These effects are more relevant in patients with underlying cardiomyopathy. Chronic ethanol intake may induce the development of a dilated cardiomyopathy, which is clinically and functionally similar to idiopathic dilated cardiomyopathy. Alcoholic cardiomyopathy is potentially reversible with abstinence. The prognosis depends on the persistence or abstinence of ethanol intake. There is a positive correlation between alcoholic cardiomyopathy and the presence of other ethanol‐related diseases, such as skeletal myopathy and cirrhosis. In patients with a specific ethanol‐related disease, the possible presence of other complications of alcoholism should be ruled out. Although there are several factors potentially implicated in the pathogenesis of alcohol‐related myocardial damage, ethanol itself may induce direct myocardial lesions, which are dose‐related and independent of nutrition, protein or ionic deficiencies. The most relevant pathogenic studies on alcoholic cardiomyopathy are based on the disruption of membrane permeability and ionic fluxes mediated by ethanol, inducing a decrease in the calcium transients through the sarcolemma and interfering with the excitation‐contraction coupling of myocytes. Cell energy depletion or protein‐turnover disruption may contribute to the deleterious effect of ethanol on the myocardium.
影响因子：
2.8
作者：
HOEK, JB;RUBIN, E
通讯作者：
RUBIN, E
乙醇抑制离体大鼠心肌细胞中电诱导的钙瞬变。
影响因子：
5
作者：
Thomas,AP;Sass,EJ;Tun-Kirchmann,TT;Rubin,E
通讯作者：
Rubin,E