An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese.
An SNP selection strategy identified IL-22 associating with susceptibility to tuberculosis in Chinese.
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DOI：
10.1038/srep00020
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发表时间：
2011
影响因子：
4.6
通讯作者：
Wang, Junwen
中科院分区：
文献类型：
--
作者：
Zhang, Guoliang;Chen, Xinchun;Chan, Long;Zhang, Mingxia;Zhu, Baohua;Wang, Lantian;Zhu, Xiuyun;Zhang, Jieyun;Zhou, Boping;Wang, Junwen
近年来的研究表明，IL-22在宿主防御中起保护作用。然而，IL-22基因多态性对人类结核病易感性的贡献仍未得到证实。我们设计了一种计算方法来选择IL-22基因中的功能SNPs，并在中国人（479例病例和358例对照）的两阶段病例对照研究中对其进行基因分型。我们发现rs 2227473，IL-22启动子区域的SNP，在我们研究的两个阶段与TB易感性相关。SNP显示相关性，p值分别为0.028和0.034，组合p值为0.0086，比值比为0.65（95%置信区间0.45-0.90）。我们进一步验证了与一个独立队列（413例病例和241例对照）的相关性。我们的功能研究表明，在非特异性和特异性刺激下，具有A等位基因的患者比不具有A等位基因的患者具有显著更高的IL-22表达。
Recent studies showed that IL-22 plays a protective role in the host defense. However, the contribution of polymorphisms of the IL-22 gene to human TB susceptibility remains untested. We have designed a computational approach to select functional SNPs in the IL-22 gene and genotyped them in a two-stage case-control study in Chinese (479 cases and 358 controls). We found that rs2227473, an SNP in the promoter region of IL-22, is associated with TB susceptibility at both stages of our study. The SNP shows associations with p-values of 0.028 and 0.034 respectively, and a combined p-value of 0.0086, with odds ratio at 0.65 (95% confidence interval 0.45–0.90). We further validated the association with an independent cohort (413 cases and 241 controls in Chinese). Our functional studies showed that patients with A allele have significantly higher IL-22 expression than those without A allele under both non-specific and specific stimulations.
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独特的，特定的IL-17-和IL-22产生的CD4+ T细胞子集有助于人类抗细菌免疫反应。
影响因子：
4.4
作者：
Scriba, Thomas J.;Kalsdorf, Barbara;Abrahams, Deborah-Ann;Isaacs, Fatima;Hofmeister, Jessica;Black, Gillian;Hassan, Hisham Y.;Wilkinson, Robert J.;Walzl, Gerhard;Gelderbloem, Sebastian J.;Mahomed, Hassan;Hussey, Gregory D.;Hanekom, Willem A.
通讯作者：
Hanekom, Willem A.
影响因子：
30.8
作者：
de Bakker, PIW;Yelensky, R;Altshuler, D
通讯作者：
Altshuler, D
DOI：
10.1046/j.1365-2370.2002.00327.x
发表时间：
2002-10-01
期刊：
EUROPEAN JOURNAL OF IMMUNOGENETICS
影响因子：
--
作者：
Lio, D;Marino, V;Caruso, C
通讯作者：
Caruso, C
影响因子：
168.9
作者：
Rossouw, M;Nel, HJ;Hoal, EG
通讯作者：
Hoal, EG
影响因子：
4.4
作者：
Dhiman, Rohan;Indramohan, Mohanalaxmi;Vankayalapati, Ramakrishna
通讯作者：
Vankayalapati, Ramakrishna