Preconception micronutrient supplementation positively affects child intellectual functioning at 6 y of age: A randomized controlled trial in Vietnam.
Preconception micronutrient supplementation positively affects child intellectual functioning at 6 y of age: A randomized controlled trial in Vietnam.
复制标题
先入为主的微量营养素补充对6岁儿童智力功能有积极影响：越南的一项随机对照试验。
DOI：
10.1093/ajcn/nqaa423
复制
发表时间：
2021-05-08
期刊：
影响因子：
--
通讯作者：
Ramakrishnan U
中科院分区：
文献类型：
--
作者：
Nguyen PH;Young MF;Tran LM;Khuong LQ;Duong TH;Nguyen HC;Truong TV;DiGirolamo AM;Martorell R;Ramakrishnan U
尽管越来越多的证据表明孕前营养对出生结局的作用，但很少有研究评估孕前营养干预对后代认知结局的长期影响。我们评估了孕前每周补充多种微量营养素（补充叶酸）或铁和叶酸（IFA）与单独补充叶酸（FA）对6-7岁后代智力功能的影响。我们跟踪了1599名在越南参加孕前补充剂双盲随机对照试验的妇女所生的后代。从基线到怀孕，妇女每周接受仅含2800 μg FA、60 mg铁和2800 μg FA的补充剂，或补充叶酸（包括IFA在内的15种微量营养素），然后每天接受产前IFA补充剂，直到分娩。我们使用韦氏儿童智力量表（Wechsler Intelligence Scale for Children）测量6-7岁儿童的全量表智商（FSIQ）和4个相关的智力功能领域[言语理解指数（VCI）、知觉推理指数（PRI）、工作记忆指数（Working Memory Index）和处理速度指数（PSI）得分]。使用ANOVA检验对所有儿童和受孕前服用补充剂≥26周的妇女所生的亚组进行组比较（符合方案分析）。按治疗组列出的具有6-7年数据的最终样本（n = 1321）的基线母体和后代出生特征以及随访时年龄相似。与FA组的后代相比，MM组的FSIQ（β = 1.7; 95%CI：0.1，3.3）、WMI（β = 1.7; 95%CI：0.2，3.2）和PSI（β = 2.5; 95%CI：0.9，4.1）更高。在符合方案分析中观察到类似结果。各治疗组的VCI和PRI无显著差异。与FA相比，在6-7岁时，孕前补充维生素B1可改善某些领域的智力功能。这些研究结果表明，孕前微量营养素干预可能对后代的认知有长期的好处。
Although there is growing evidence on the role of preconception nutrition for birth outcomes, very few studies have evaluated the long-term effects of nutrition interventions during the preconception period on offspring cognitive outcomes. We evaluate the impact of preconception weekly multiple micronutrients (MMs) or iron and folic acid (IFA) supplementation compared with folic acid (FA) alone on offspring intellectual functioning at age 6–7 y. We followed 1599 offspring born to women who participated in a double-blinded randomized controlled trial of preconception supplementation in Vietnam. Women received weekly supplements containing either 2800 μg FA only, 60 mg iron and 2800 μg FA, or MMs (15 micronutrients including IFA) from baseline until conception, followed by daily prenatal IFA supplements until delivery. We used the Wechsler Intelligence Scale for Children to measure full-scale IQ (FSIQ) and 4 related domains of intellectual functioning [Verbal Comprehension Index (VCI), Perceptual Reasoning Index (PRI), Working Memory Index (WMI), and Processing Speed Index (PSI) scores] at 6–7 y. Group comparisons were done using ANOVA tests for all children and the subgroup born to women who consumed the supplements ≥26 wk before conception (per-protocol analyses). The final sample with data at 6–7 y (n = 1321) was similar for baseline maternal and offspring birth characteristics and age at follow-up by treatment group. Compared with the offspring in the FA group, those in the MM group had higher FSIQ (β = 1.7; 95% CI: 0.1, 3.3), WMI (β = 1.7; 95% CI: 0.2, 3.2), and PSI (β = 2.5; 95% CI: 0.9, 4.1). Similar findings were observed in the per-protocol analyses. There were no significant differences by treatment group for VCI and PRI. Preconception supplementation with MMs improved certain domains of intellectual functioning at age 6–7 y compared with FA. These findings suggest the potential for preconception micronutrient interventions to have long-term benefits for offspring cognition.
登录
查看更多内容
DOI：
10.1016/s0140-6736(16)31389-7
发表时间：
2017-01-07
期刊：
Lancet (London, England)
影响因子：
--
作者：
Black MM;Walker SP;Fernald LCH;Andersen CT;DiGirolamo AM;Lu C;McCoy DC;Fink G;Shawar YR;Shiffman J;Devercelli AE;Wodon QT;Vargas-Barón E;Grantham-McGregor S;Lancet Early Childhood Development Series Steering Committee
通讯作者：
Lancet Early Childhood Development Series Steering Committee
影响因子：
4.5
作者：
Nguyen PH;Lowe AE;Martorell R;Nguyen H;Pham H;Nguyen S;Harding KB;Neufeld LM;Reinhart GA;Ramakrishnan U
通讯作者：
Ramakrishnan U
影响因子：
12.7
作者：
FREEMAN, HE;KLEIN, RE;LECHTIG, A
通讯作者：
LECHTIG, A
影响因子：
3.5
作者：
Filmer, D;Pritchett, LH
通讯作者：
Pritchett, LH
影响因子：
4.5
作者：
Gonzalez-Casanova, Ines;Phuong Hong Nguyen;Ramakrishnan, Usha
通讯作者：
Ramakrishnan, Usha