A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis.
A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis.
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DOI：
10.1186/s12957-015-0459-z
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发表时间：
2015-02-21
影响因子：
3.2
通讯作者：
Nakamura S
中科院分区：
文献类型：
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作者：
Ohta M;Moriyama M;Goto Y;Kawano S;Tanaka A;Maehara T;Furukawa S;Hayashida JN;Kiyoshima T;Shimizu M;Arinobu Y;Nakamura S
IgG 4相关泪腺炎和涎腺炎（IgG 4-DS），即所谓的Mikulicz病，其特征在于血清IgG 4升高和腺组织中IgG 4阳性浆细胞浸润。最近，一些研究报告了在IgG 4相关疾病背景下发生的恶性淋巴瘤和产生IgG 4的恶性淋巴瘤（非IgG 4相关疾病）。我们报告的情况下，70岁的男子谁是强烈怀疑IgG 4-DS，因为高血清IgG 4浓度（215毫克/分升）和双侧腮腺和颌下腺肿胀。对颈部淋巴结和部分颌下腺进行活检。这些组织病理学结果随后证实了边缘区B细胞淋巴瘤的诊断。IgG 4-DS与其他疾病（包括干燥综合征、结节病、Castleman病、Wegener肉芽肿病、淋巴瘤和癌症）的鉴别诊断是必要的。我们认为，肿胀病变的活检是重要的IgG 4-DS的明确诊断，并讨论在这种情况下的发展机制。
IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS), so-called Mikulicz’s disease, is characterized by elevated serum IgG4 and infiltration of IgG4-positive plasma cells in glandular tissues. Recently, several studies reported both malignant lymphoma developed on the background of IgG4-associated conditions and IgG4-producing malignant lymphoma (non-IgG4-related disease). We report on the case of a 70-year-old man who was strongly suspected IgG4-DS because of high serum IgG4 concentration (215 mg/dl) and bilateral swelling of parotid and submandibular glands. Biopsies of cervical lymph node and a portion of submandibular gland were performed. These histopathological findings subsequently confirmed a diagnosis of marginal zone B cell lymphoma. Differential diagnosis of IgG4-DS is necessary from other disorders, including Sjögren’s syndrome, sarcoidosis, Castleman’s disease, Wegener’s granulomatosis, lymphoma, and cancer. We suggest that biopsy of swollen lesions is important for a definitive diagnosis of IgG4-DS and discuss the mechanism of development in this case.
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影响因子：
2.2
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2.2
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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