Beyond MITF: Multiple transcription factors directly regulate the cellular phenotype in melanocytes and melanoma.
Beyond MITF: Multiple transcription factors directly regulate the cellular phenotype in melanocytes and melanoma.
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DOI：
10.1111/pcmr.12611
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发表时间：
2017-09
影响因子：
4.3
通讯作者：
Cornell RA
中科院分区：
文献类型：
--
作者：
Seberg HE;Van Otterloo E;Cornell RA
MITF调控黑素细胞发育的多个步骤，包括从神经脊到生长、存活和终末分化的指定。此外，MITF活性的水平决定了黑色素瘤细胞的表型，无论是侵袭性的、增殖性的还是分化的。然而，MITF并不是单独行动的。在这里，我们回顾了关于共同调节MITF依赖基因的转录因子的文献。CHIP-SEQ研究表明，转录因子Sox10、YY1和TFAP2A共同占据了黑素细胞中MITF结合的调节元件的亚群。单基因座的分析也支持LEF1、RB1、IRF4和PAX3与MITF的结合作用，而序列基序分析表明，额外的转录因子与MITF在许多黑素细胞特异性调控元件上共定位。然而，这些MITF合作者的确切生化功能及其对基因表达的贡献仍有待阐明。类似于胚胎发生过程中形态形成组织中的转录网络，我们预计MITF活性的水平不仅受激活的MITF浓度控制，还受额外的转录因子控制，这些转录因子可以定量或定性地影响MITF靶基因的表达。
MITF governs multiple steps in the development of melanocytes, including specification from neural crest, growth, survival, and terminal differentiation. In addition, the level of MITF activity determines the phenotype adopted by melanoma cells, whether invasive, proliferative, or differentiated. However, MITF does not act alone. Here, we review literature on the transcription factors that co-regulate MITF-dependent genes. ChIP-seq studies have indicated that the transcription factors SOX10, YY1, and TFAP2A co-occupy subsets of regulatory elements bound by MITF in melanocytes. Analyses at single loci also support roles for LEF1, RB1, IRF4, and PAX3 acting in combination with MITF, while sequence motif analyses suggest that additional transcription factors colocalize with MITF at many melanocyte-specific regulatory elements. However, the precise biochemical functions of each of these MITF collaborators and their contributions to gene expression remain to be elucidated. Analogous to the transcriptional networks in morphogen-patterned tissues during embryogenesis, we anticipate that the level of MITF activity is controlled not only by the concentration of activated MITF, but also by additional transcription factors that either quantitatively or qualitatively influence the expression of MITF-target genes.
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影响因子：
4.5
作者：
Cusanovich DA;Pavlovic B;Pritchard JK;Gilad Y
通讯作者：
Gilad Y
影响因子：
64.8
作者：
Bertolotto, Corine;Lesueur, Fabienne;Bressac-de Paillerets, Brigitte
通讯作者：
Bressac-de Paillerets, Brigitte
影响因子：
7.3
作者：
Atchison ML
通讯作者：
Atchison ML
影响因子：
4.8
作者：
Begon, DY;Delacroix, L;Winkler, R
通讯作者：
Winkler, R
影响因子：
3.5
作者：
Bondurand, N;Pingault, V;Goossens, M
通讯作者：
Goossens, M