Risk factors for pandemic (H1N1) 2009 seroconversion among adults, Singapore, 2009.
Risk factors for pandemic (H1N1) 2009 seroconversion among adults, Singapore, 2009.
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DOI：
10.3201/eid1708.101270
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发表时间：
2011-08
影响因子：
11.8
通讯作者：
Chia KS
中科院分区：
文献类型：
--
作者：
Lim WY;Chen CH;Ma Y;Chen MI;Lee VJ;Cook AR;Tan LW;Flores Tabo N Jr;Barr I;Cui L;Lin RT;Leo YS;Chia KS
在2009年6月至9月新加坡大流行(H1N1)暴发期间，共有828名居住在社区的成年人接受了研究。在暴发前采集了基线血样，在随访期间又采集了2个样本。血清转换的定义是2009年大流行(H1N1)的抗体效价增加4倍，通过血凝抑制来确定。男性比女性更有可能发生血清转换(调整后的平均危险比[HR]2.23，平均95%可信区间[CI]1.26-3.93)；马来人比中国人更容易发生血清转换(HR为2.67，95%CI为1.04-6.91)。在研究期间，新加坡以外的旅行与血清转换率(HR 1.76，95%CI 1.11-2.78)以及使用公共交通工具(HR 1.81，95%CI 1.05-3.09)有关。基线抗体滴度高与血清转换率降低有关。这项研究提出了可能的干预领域，以减少未来流感暴发期间的传播。
A total of 828 community-dwelling adults were studied during the course of the pandemic (H1N1) 2009 outbreak in Singapore during June–September 2009. Baseline blood samples were obtained before the outbreak, and 2 additional samples were obtained during follow-up. Seroconversion was defined as a >4-fold increase in antibody titers to pandemic (H1N1) 2009, determined by using hemagglutination inhibition. Men were more likely than women to seroconvert (mean adjusted hazards ratio [HR] 2.23, mean 95% confidence interval [CI] 1.26–3.93); Malays were more likely than Chinese to seroconvert (HR 2.67, 95% CI 1.04–6.91). Travel outside Singapore during the study period was associated with seroconversion (HR 1.76, 95% CI 1.11–2.78) as was use of public transport (HR 1.81, 95% CI 1.05–3.09). High baseline antibody titers were associated with reduced seroconversion. This study suggests possible areas for intervention to reduce transmission during future influenza outbreaks.
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影响因子：
6.4
作者：
France, Anne Marie;Jackson, Michael;Hadler, James
通讯作者：
Hadler, James
DOI：
10.1136/bmj.c2424
发表时间：
2010-05-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Baker MG;Thornley CN;Mills C;Roberts S;Perera S;Peters J;Kelso A;Barr I;Wilson N
通讯作者：
Wilson N
DOI：
10.1056/nejmoa0905498
发表时间：
2009-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Cauchemez S;Donnelly CA;Reed C;Ghani AC;Fraser C;Kent CK;Finelli L;Ferguson NM
通讯作者：
Ferguson NM
影响因子：
2.7
作者：
BRESLOW, N
通讯作者：
BRESLOW, N
影响因子：
5.5
作者：
Fedson, DS;Kunze, M;Vidmar, S
通讯作者：
Vidmar, S